Trial reportOphthalmology2022
Postoperative Complications in the Primary Tube Versus Trabeculectomy Study During 5 Years of Follow-up.
Trial report in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 51 citations in OpenAlex.
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study.Ophthalmology. GlaucomaTrial
- Retrospective analysis of indications and outcomes of trabecular micro-bypass stent implantation in Indian eyes.Indian journal of ophthalmology · 2026Article
- Preservation and Reuse of KLEx Lenticules: From Biobanking to Therapeutic and Refractive Innovations.Bioengineering (Basel, Switzerland) · 2026Review
- Corneal tomography and endothelial cell density after Paul glaucoma implant surgery.Acta ophthalmologica · 2026Article
- Clinical Outcomes and Risk Factors for Surgical Failure Following Baerveldt Glaucoma Implant Surgery as a Primary Filtering Procedure.Journal of clinical medicine · 2026Article
- The Incidence of Clinically Significant Hypotony After Trabeculectomy.Journal of glaucoma · 2026Observational
- Cystoid macular oedema after trabeculectomy versus tube shunt surgery in non-diabetic patients.BMJ open ophthalmology · 2026Article
- A Comparison of the Efficacy and Safety of Modified Baerveldt Drainage Implants versus Ahmed Glaucoma Valves After 1 Year of Follow-Up.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Intermediate Outcomes of a Novel Flat Glaucoma Drainage Device in Uncontrolled Primary Open Angle Glaucoma.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Glaucoma drainage device erosion rescued with upper eyelid forniceal conjunctival pedicle flap.American journal of ophthalmology case reports · 2025Article
- Short-term efficacy and safety of A-stream glaucoma shunt: a 6-month study.Eye (London, England) · 2025Article
- Clinical Outcomes of XEN45 Gel Stent Implantation (Ab Externo, Open Conjunctival Approach) versus Trabeculectomy: A Real-World Study.Korean journal of ophthalmology : KJO · 2025Article
- Safety and effectiveness of a new minimally invasive glaucoma surgery namely trabeculotome tunneling trabeculoplasty in primary open-angle glaucoma.Frontiers in medicine · 2025Article
- One year clinical outcomes with a novel canaloplasty device in mild to severe open angle glaucoma.International journal of ophthalmology · 2025Article
- Retrobulbar/intraconal tube placement in patients with glaucoma: Ahmed FP-7 and tube extender case series with 1 year follow-up.Frontiers in ophthalmology · 2025Article
- Navigating postoperative complications: Uveitis-glaucoma-hyphema syndrome after Ahmed glaucoma valve implantation.World journal of clinical cases · 2024Article
- Aqueous shunt exposure repair: outcomes and risk factors for recurrence.Eye (London, England) · 2024Article
- Postoperative Outcomes of PreserFlo MicroShunt in Patients with Exfoliation Glaucoma.Journal of clinical medicine · 2024Article
- Comparison of clinical outcomes between gonioscopy-assisted transluminal trabeculotomy and trabeculectomy in advanced-stage pseudoexfoliation glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeTo describe postoperative complications encountered in the Primary Tube Versus Trabeculectomy (PTVT) Study during 5 years of follow-up.
designMulticenter randomized clinical trial.
participantsA total of 242 eyes of 242 patients with medically uncontrolled glaucoma and no previous incisional ocular surgery, including 125 patients in the tube group and 117 patients in the trabeculectomy group.
methodsPatients were enrolled at 16 clinical centers and randomly assigned to treatment with a tube shunt (350-mm
main outcome measuresSurgical complications, reoperations for complications, visual acuity, and cataract progression.
resultsEarly postoperative complications occurred in 24 patients (19%) in the tube group and 40 patients (34%) in the trabeculectomy group (P = 0.013). Late postoperative complications developed in 27 patients (22%) in the tube group and 32 patients (27%) in the trabeculectomy group (P = 0.37). Serious complications producing vision loss and/or requiring a reoperation were observed in 3 patients (2%) in the tube group and 9 patients (8%) in the trabeculectomy group (P = 0.11). Cataract progression was seen in 65 patients (52%) in the tube group and 52 patients (44%) in the trabeculectomy group (P = 0.30). Surgical complications were not associated with a higher rate of treatment failure (P = 0.61), vision loss (P = 1.00), or cataract progression (P = 0.77)
conclusionsA large number of surgical complications were observed in the PTVT Study, but most were transient and self-limited. The incidence of early postoperative complications was higher following trabeculectomy with MMC than with tube shunt surgery. The rates of late postoperative complications, serious complications, and cataract progression were similar with both surgical procedures after 5 years of follow-up. Surgical complications did not increase the risk of treatment failure, vision loss, or cataract progression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.