ArticleCerebral cortex (New York, N.Y. : 1991)2023
Biological constraints on stereotaxic targeting of functionally-defined cortical areas.
Article in Cerebral cortex (New York, N.Y. : 1991), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 18 citations in OpenAlex.
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Context-dependent effects of SOM neurons to enhance the responses of corticocollicular neurons to repetitive sounds.iScience · 2026Article
- Orbitofrontal cortex drives predictive filtering of sensory responses.Nature neuroscience · 2026Article
- Large cranial windows distort sensory maps and degrade feature integration in higher-order cortex.bioRxiv : the preprint server for biology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex.iScience · 2025Article
- Noncanonical short-latency auditory pathway directly activates deep cortical layers.Nature communications · 2025Article
- Movement-Related Modulation in Mouse Auditory Cortex Is Widespread Yet Locally Diverse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Selectivity to acoustic features of human speech in the auditory cortex of the mouse.Hearing research · 2024Article
- Tonotopic organization of auditory cortex in awake marmosets revealed by multi-modal wide-field optical imaging.Current research in neurobiology · 2024Article
- Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia.Angiogenesis · 2023Article
- Potentiation of cholinergic and corticofugal inputs to the lateral amygdala in threat learning.Cell reports · 2023Article
- Stimulus-Specific Prediction Error Neurons in Mouse Auditory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Movement-related modulation in mouse auditory cortex is widespread yet locally diverse.bioRxiv : the preprint server for biology · 2023Article
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.Scientific reports · 2023Article
- Distinct nonlinear spectrotemporal integration in primary and secondary auditory cortices.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
Understanding computational principles in hierarchically organized sensory systems requires functional parcellation of brain structures and their precise targeting for manipulations. Although brain atlases are widely used to infer area locations in the mouse neocortex, it has been unclear whether stereotaxic coordinates based on standardized brain morphology accurately represent functional domains in individual animals. Here, we used intrinsic signal imaging to evaluate the accuracy of area delineation in the atlas by mapping functionally-identified auditory cortices onto bregma-based stereotaxic coordinates. We found that auditory cortices in the brain atlas correlated poorly with the true complexity of functional area boundaries. Inter-animal variability in functional area locations predicted surprisingly high error rates in stereotaxic targeting with atlas coordinates. This variability was not simply attributed to brain sizes or suture irregularities but instead reflected differences in cortical geography across animals. Our data thus indicate that functional mapping in individual animals is essential for dissecting cortical area-specific roles with high precision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.