Evidence map›Paper›PMID 35834797›Full record

ArticleMolecular pharmaceutics2022

Effect of Paclitaxel Stereochemistry on X-ray-Triggered Release of Paclitaxel from CaWO

Kaustabh Sarkar, Sandra E Torregrossa-Allen, Bennett D Elzey, Sanjeev Narayanan, Mark P Langer, Gregory A Durm, You-Yeon Won

Erratum issuedAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

  1. RapidActa pharmaceutica Sinica. B · 2026
    Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kaustabh SarkarDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.
Sandra E Torregrossa-AllenPurdue University Center of Cancer Research, West Lafayette, Indiana 47907, United States.
Bennett D ElzeyPurdue University Center of Cancer Research, West Lafayette, Indiana 47907, United States.
Sanjeev NarayananDepartment of Comparative Pathobiology, Purdue University, West Lafayette, Indiana 47907, United States.
Mark P LangerDepartment of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Gregory A DurmDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
You-Yeon WonDavidson School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States.ORCID 0000-0002-8347-6375
Purdue University West Lafayette · USIndiana University School of Medicine

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
NCI NIH HHS P30 CA023168
6 · The paper itself

Abstract

For many locally advanced tumors, the chemotherapy-radiotherapy (CT-RT) combination ("chemoradiation") is currently the standard of care. Intratumoral (IT) CT-based chemoradiation has the potential to overcome the limitations of conventional systemic CT-RT (side effects). For maximizing the benefits of IT CT-RT, our laboratory has previously developed a radiation-controlled drug release formulation, in which anticancer drug paclitaxel (PTX) and radioluminescent CaWO

Indexed as

NanoparticlesNeoplasmsAnimalsCell Line, TumorDrug CarriersHumansMicePaclitaxelPolyethylene GlycolsWaterX-RaysDrug Carriersmonomethoxypolyethyleneglycol-polylactide block copolymerPaclitaxelPolyethylene GlycolsWaterpaclitaxelpoly(ethylene glycol)−poly(D,L-lactic acid)radiation-controlled drug releaseradioluminescent CaWO4 nanoparticlestereochemistry

Identifiers

PMID35834797
PMCPMC11975462
OpenAlexW4285389409

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.