Evidence map›Paper›PMID 35834733›Full record

ArticleBlood advances2022

Combined BCL2 and BTK inhibition in CLL demonstrates efficacy after monotherapy with both classes.

Jonathan M Hyak, Ying Huang, Kerry A Rogers, Seema A Bhat, Michael R Grever, John C Byrd, Adam S Kittai, Dan Jones, Cecelia R Miller, Jennifer A Woyach

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Article
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  8. Article
  9. Review
  10. Novel therapies and combinations in CLL refractory to BTK inhibitors and venetoclax.Hematology. American Society of Hematology. Education Program · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jonathan M HyakDepartment of Medicine and Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.ORCID 0000-0001-7039-0655
Ying HuangDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0001-9910-1212
Kerry A RogersDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0001-5748-7874
Seema A BhatDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0001-7844-0856
Michael R GreverDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0002-1605-7875
John C ByrdDepartment of Internal Medicine, The University of Cincinnati, Cincinnati, OH.ORCID 0000-0002-8778-1000
Adam S KittaiDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.
Dan JonesDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0002-4688-3780
Cecelia R MillerDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.
Jennifer A WoyachDepartment of Pathology, The Ohio State University Comprehensive Cancer Center, Columbus, OH; and.ORCID 0000-0002-3403-9144
The Ohio State University · USThe Ohio State University Wexner Medical Center · USUniversity of Cincinnati · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
Targeted Therapy for Lymphoid MalignanciesR01CA177292 · NCI · OHIO STATE UNIVERSITY · PI ROGERS, KERRY ANNE, WOYACH, JENNIFER A. · 2013 to 2025
$5.3M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA177292
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellAgammaglobulinaemia Tyrosine KinaseHumansProto-Oncogene Proteins c-bcl-2PyrimidinesAgammaglobulinaemia Tyrosine KinaseBCL2 protein, humanProto-Oncogene Proteins c-bcl-2Pyrimidines

Identifiers

PMID35834733
PMCPMC9631640
OpenAlexW4285390717

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.