ArticleThe Plant journal : for cell and molecular biology2022
The evolutionary patterns of barley pericentromeric chromosome regions, as shaped by linkage disequilibrium and domestication.
Article in The Plant journal : for cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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7 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- New loci and candidate genes in spring two-rowed barley detected through meta-analysis of a field trial European network.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Pooled it
- Integrated Comparative Genomics and Population Genomics Reveal the Genomic and Epigenomic Basis of Barley (Plants (Basel, Switzerland) · 2026Article
- Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome.The New phytologist · 2026Article
- Variation at the major facilitator superfamilyFrontiers in plant science · 2025Article
- Construction of high-density bin genetic map and QTL mapping of fruit aroma in longan (Frontiers in plant science · 2025Article
- Genetic erosion in domesticated barley and a hypothesis of a North African centre of diversity.Ecology and evolution · 2024Article
- A pipeline for identification of causal mutations in barley identifies Xantha-j as the chlorophyll synthase gene.Plant physiology · 2024Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
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Abstract
The distribution of recombination events along large cereal chromosomes is uneven and is generally restricted to gene-rich telomeric ends. To understand how the lack of recombination affects diversity in the large pericentromeric regions, we analysed deep exome capture data from a final panel of 815 Hordeum vulgare (barley) cultivars, landraces and wild barleys, sampled from across their eco-geographical ranges. We defined and compared variant data across the pericentromeric and non-pericentromeric regions, observing a clear partitioning of diversity both within and between chromosomes and germplasm groups. Dramatically reduced diversity was found in the pericentromeres of both cultivars and landraces when compared with wild barley. We observed a mixture of completely and partially differentiated single-nucleotide polymorphisms (SNPs) between domesticated and wild gene pools, suggesting that domesticated gene pools were derived from multiple wild ancestors. Patterns of genome-wide linkage disequilibrium, haplotype block size and number, and variant frequency within blocks showed clear contrasts among individual chromosomes and between cultivars and wild barleys. Although most cultivar chromosomes shared a single major pericentromeric haplotype, chromosome 7H clearly differentiated the two-row and six-row types associated with different geographical origins. Within the pericentromeric regions we identified 22 387 non-synonymous SNPs, 92 of which were fixed for alternative alleles in cultivar versus wild accessions. Surprisingly, only 29 SNPs found exclusively in the cultivars were predicted to be 'highly deleterious'. Overall, our data reveal an unconventional pericentromeric genetic landscape among distinct barley gene pools, with different evolutionary processes driving domestication and diversification.
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