Evidence map›Paper›PMID 35834575›Full record

ArticlePloS one2022

Follow-up lung ultrasound to monitor lung failure in COVID-19 ICU patients.

Michaela Barnikel, Annabel Helga Sophie Alig, Sofia Anton, Lukas Arenz, Henriette Bendz, Alessia Fraccaroli, Jeremias Götschke, Marlies Vornhülz, Philipp Plohmann, Tobias Weiglein and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Michaela BarnikelDepartment of Medicine V, University Hospital, LMU, Munich, Germany.ORCID 0000-0001-6965-0018
Annabel Helga Sophie AligDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Sofia AntonDepartment of Medicine II, University Hospital, LMU, Munich, Germany.ORCID 0000-0002-7681-3476
Lukas ArenzDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Henriette BendzDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Alessia FraccaroliDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Jeremias GötschkeDepartment of Medicine V, University Hospital, LMU, Munich, Germany.
Marlies VornhülzDepartment of Medicine II, University Hospital, LMU, Munich, Germany.
Philipp PlohmannDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Tobias WeigleinDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Hans Joachim StemmlerDepartment of Medicine III, University Hospital, LMU, Munich, Germany.
Stephanie-Susanne StecherDepartment of Medicine II, University Hospital, LMU, Munich, Germany.ORCID 0000-0001-6715-1020
LMU Klinikum · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPoint-of-care lung ultrasound (LU) is an established tool in the first assessment of patients with coronavirus disease (COVID-19). To assess the progression or regression of respiratory failure in critically ill patients with COVID-19 on Intensive Care Unit (ICU) by using LU. MATERIALS AND

methodsWe analyzed all patients admitted to Internal Intensive Care Unit, Ludwig-Maximilians-University (LMU) of Munich, from March 2020 to December 2020 suffering lung failure caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). LU was performed according to a standardized protocol at baseline and at follow up every other day for the first 15 days using a lung ultrasound score (LUSS). Ventilation data were collected simultaneously.

resultsOur study included 42 patients. At admission to ICU, 19 of them (45%) were mechanically ventilated. Of the non-invasive ventilated ones (n = 23, 55%), eleven patients required invasive ventilation over the course. While LUS did not differ at admission to ICU between the invasive ventilated ones (at baseline or during ICU stay) compared to the non-invasive ventilated ones (12±4 vs 11±2 points, p = 0.2497), LUS was significantly lower at d7 for those, who had no need for invasive ventilation over the course (13±5 vs 7±4 points, p = 0.0046). Median time of invasive ventilation counted 18 days; the 90-day mortality was 24% (n = 10) in our cohort. In case of increasing LUS between day 1 (d1) and day 7 (d7), 92% (n = 12/13) required invasive ventilation, while it was 57% (n = 10/17) in case of decreasing LUS. At d7 we found significant correlation between LU and FiO2 (Pearson 0.591; p = 0.033), p/F ratio (Pearson -0.723; p = 0.005), PEEP (Pearson 0.495; p = 0.043), pplat (Pearson 0.617; p = 0.008) and compliance (Pearson -0.572; p = 0.016).

conclusionLUS can be a useful tool in monitoring of progression and regression of respiratory failure and in indicating intubation in patients with COVID-19 in the ICU.

Indexed as

COVID-19Respiratory InsufficiencyFollow-Up StudiesHumansIntensive Care UnitsLungRespiration, ArtificialRNA, ViralSARS-CoV-2RNA, Viral

Identifiers

PMID35834575
PMCPMC9282475
OpenAlexW4285495470

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.