Evidence map›Paper›PMID 35834272›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Studies of ultrastructure, gene expression, and marker analysis reveal that mouse bladder PDGFRA

Dennis R Clayton, Wily G Ruiz, Marianela G Dalghi, Nicolas Montalbetti, Marcelo D Carattino, Gerard Apodaca

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

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  12. Defining the molecular fingerprint of bladder and kidney fibroblasts.American journal of physiology. Renal physiology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dennis R ClaytonDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Wily G RuizDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Marianela G DalghiDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Nicolas MontalbettiDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-2897-9540
Marcelo D CarattinoDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-1901-1618
Gerard ApodacaDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-2432-4435
University of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARATTINO, MARCELO DANIEL · 2008 to 2022
$13.4M
Role of PIEZO Channels in Bladder Function and DysfunctionR01DK119183 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L, CARATTINO, MARCELO DANIEL · 2019 to 2023
$3.0M
Leica Stellaris Confocal for Kidney Imaging CoreS10OD028596 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2021 to 2021
$596k
NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK119183NIH HHS S10 OD028596
6 · The paper itself

Abstract

Fibroblasts are crucial to normal and abnormal organ and tissue biology, yet we lack basic insights into the fibroblasts that populate the bladder wall. Candidates may include bladder interstitial cells (also referred to as myofibroblasts, telocytes, and interstitial cells of Cajal-like cells), which express the fibroblast-associated marker PDGFRA along with VIM and CD34 but whose form and function remain enigmatic. By applying the latest insights in fibroblast transcriptomics, coupled with studies of gene expression, ultrastructure, and marker analysis, we observe the following:

Indexed as

Interstitial Cells of CajalAnimalsAntigens, CD34FibroblastsGene ExpressionMiceMucous MembraneReceptor Protein-Tyrosine KinasesUrinary BladderAntigens, CD34Receptor Protein-Tyrosine Kinasesbladderfibroblastinterstitial cellPDGFRAteolcyte

Identifiers

PMID35834272
PMCPMC9394772
OpenAlexW4285389118

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.