Evidence map›Paper›PMID 35834180›Full record

Trial reportJournal of agricultural and food chemistry2022

Impact of Beer and Nonalcoholic Beer Consumption on the Gut Microbiota: A Randomized, Double-Blind, Controlled Trial.

Cláudia Marques, Liliana Dinis, Inês Barreiros Mota, Juliana Morais, Shámila Ismael, José B Pereira-Leal, Joana Cardoso, Pedro Ribeiro, Helena Beato, Mafalda Resende and 7 more

Open access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of agricultural and food chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Cláudia MarquesNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Liliana DinisNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Inês Barreiros MotaNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Juliana MoraisNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Shámila IsmaelNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
José B Pereira-LealOphiomics─Precision Medicine, Lisboa 1600-514, Portugal.
Joana CardosoOphiomics─Precision Medicine, Lisboa 1600-514, Portugal.
Pedro RibeiroCentro de Medicina Laboratorial Germano de Sousa, Lisboa 1600-513, Portugal.
Helena BeatoCATAA─Centro de Apoio Tecnológico Agro Alimentar, Castelo Branco 6000-459, Portugal.
Mafalda ResendeCATAA─Centro de Apoio Tecnológico Agro Alimentar, Castelo Branco 6000-459, Portugal.
Christophe Espírito SantoCATAA─Centro de Apoio Tecnológico Agro Alimentar, Castelo Branco 6000-459, Portugal.
Ana Paula CortezNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
André RosárioNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Diogo PestanaNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Diana TeixeiraNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Ana FariaNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.ORCID 0000-0002-5165-9513
Conceição CalhauNutrição e Metabolismo, Faculdade de Ciências Médicas/NOVA Medical School, Universidade NOVA de Lisboa, Lisboa 1169-056, Portugal.
Centre for Health Technology and Services Research · PTUniversidade Nova de Lisboa · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota modulation might constitute a mechanism mediating the effects of beer on health. In this randomized, double-blinded, two-arm parallel trial, 22 healthy men were recruited to drink 330 mL of nonalcoholic beer (0.0% v/v) or alcoholic beer (5.2% v/v) daily during a 4-week follow-up period. Blood and faecal samples were collected before and after the intervention period. Gut microbiota was analyzed by 16S rRNA gene sequencing. Drinking nonalcoholic or alcoholic beer daily for 4 weeks did not increase body weight and body fat mass and did not changed significantly serum cardiometabolic biomarkers. Nonalcoholic and alcoholic beer increased gut microbiota diversity which has been associated with positive health outcomes and tended to increase faecal alkaline phosphatase activity, a marker of intestinal barrier function. These results suggest the effects of beer on gut microbiota modulation are independent of alcohol and may be mediated by beer polyphenols.

Indexed as

BeerGastrointestinal MicrobiomeAlkaline PhosphataseBiomarkersHumansMaleRNA, Ribosomal, 16SAlkaline PhosphataseBiomarkersRNA, Ribosomal, 16Salcoholbeergut microbiotanonalcoholic beerpolyphenols

Identifiers

PMID35834180
PMCPMC9776556
OpenAlexW4282972530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.