ArticleACS nano2022
Effects of Scaffold Shape on Bone Regeneration: Tiny Shape Differences Affect the Entire System.
Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Reconstruction of a segmental bone defect using vascularized tissue-engineered bone substitutes: An animal study.PloS one · 2026Article
- Expert Perspectives: Evidence-Based Applications of Polynucleotides (PNs) in Aesthetic Medicine and Dermatology.Clinical, cosmetic and investigational dermatology · 2026Article
- Compositionally Optimized Bone Scaffolds Based on Carbonate Apatite and Silver Phosphate for Osteogenesis, Scaffold Resorption, and Photoactivated Antibacterial Activity.ACS applied bio materials · 2025Article
- Long-term follow-up of patients with large segmental bone defects treated with 3D-printed polycaprolactone/tricalcium phosphate scaffolds.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Strategic Uniaxial Macropore Sizing for Honeycomb-Structured Scaffolds for Enhanced Bone Reconstruction in Segmental Bone Defects.ACS omega · 2025Article
- mRNA encoding bone morphogenetic protein-2 facilitated peri-implant bone formation of titanium implants placed in rat femurs.Scientific reports · 2025Article
- Enhanced Bioactivity of Chitosan-Alginate-Riboflavin Liquid-Exfoliated Molybdenum Disulfide Nanosheets for Bone Tissue Engineering Applications.ACS omega · 2024Article
- Personalized bioceramic grafts for craniomaxillofacial bone regeneration.International journal of oral science · 2024Review
- Carbonate Apatite Honeycomb Scaffold-Based Drug Delivery System for Repairing Osteoporotic Bone Defects.ACS applied materials & interfaces · 2024Article
- Silver phosphate-modified carbonate apatite honeycomb scaffolds for anti-infective and pigmentation-free bone tissue engineering.Materials today. Bio · 2024Article
- Polynucleotides in Aesthetic Medicine: A Review of Current Practices and Perceived Effectiveness.International journal of molecular sciences · 2024Review
- Review
- High-resolution 3-D scanning electron microscopy (SEM) images of DOTSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Lamellar Septa-like Structured Carbonate Apatite Scaffolds with Layer-by-Layer Fracture Behavior for Bone Regeneration.Biomimetics (Basel, Switzerland) · 2024Article
- 3D printing materials and 3D printed surgical devices in oral and maxillofacial surgery: design, workflow and effectiveness.Regenerative biomaterials · 2024Review
- Effects of Space Dimensionality within Scaffold for Bone Regeneration with Large and Oriented Blood Vessels.Materials (Basel, Switzerland) · 2023Article
- Reconstruction of Load-Bearing Segmental Bone Defects Using Carbonate Apatite Honeycomb Blocks.ACS materials Au · 2023Article
- Gear-shaped carbonate apatite granules with a hexagonal macropore for rapid bone regeneration.Computational and structural biotechnology journal · 2023Article
- Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects.International journal of nanomedicine · 2023Article
- Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation.Bioengineering (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although studies on scaffolds for tissue generation have mainly focused on the chemical composition and pore structure, the effects of scaffold shape have been overlooked. Scaffold shape determines the scaffold surface area (SA) at the single-scaffold level (i.e., microscopic effects), although it also affects the amount of interscaffold space in the tissue defect at the whole-system level (i.e., macroscopic effects). To clarify these microscopic and macroscopic effects, this study reports the osteogenesis abilities of three types of carbonate apatite granular scaffolds with different shapes, namely, irregularly shaped dense granules (DGs) and two types of honeycomb granules (HCGs) with seven hexagonal channels (∼255 μm in length between opposite sides). The HCGs possessed either 12 protuberances (∼75 μm in length) or no protuberances. Protuberances increased the SA of each granule by 3.24 mm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.