ArticleActa neurologica Scandinavica2022
Early post-traumatic seizures in hospitalized patients with traumatic brain injury.
Article in Acta neurologica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Early post-traumatic seizure as severity predictor of traumatic brain injury: A meta-analysis and systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Pooled it
- Civilian penetrating traumatic brain injury in South-East Norway.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Blood biomarker outliers and clinical events during intensive care in patients with traumatic brain injury.Brain & spine · 2026Article
- KEPPRA: Key Epilepsy Prognostic Parameters with Radiomics in Acute Subdural Hematoma Before Craniotomy.Brain sciences · 2025Article
- Two-year longitudinal and prospective electroencephalographic follow-up in patients with TBI: can early EEG and CT findings predict post-traumatic epilepsy?Frontiers in neurology · 2025Article
- Which risk factors significantly influence the outcome of traumatic brain injured patients with alcohol use disorder?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Seizure-Related Head Injuries: A Narrative Review.Brain sciences · 2024Review
- Article
- Assessing risk factors associated with breakthrough early post-traumatic seizures in patients receiving phenytoin prophylaxis.Frontiers in neurology · 2023Article
- Early post-traumatic seizures in hospitalized patients with traumatic brain injury.Acta neurologica Scandinavica · 2022Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesEarly post-traumatic seizures (EPTS) are a well-known complication of traumatic brain injury (TBI). EPTS increase the risk of secondary brain injury and may cause significant challenges during the period of critical care. Routine use of prophylactic anti-seizure medication is controversial due to conflicting reports on efficacy and risk of adverse effects. The purpose of this study was to expand the understanding of EPTS by examining incidence and risk factors in hospitalized patients with TBI. MATERIAL &
methodsAdult patients with TBI and evidence of intracranial injury admitted to Oslo University Hospital between 2015 and 2019 were identified from the Oslo TBI Registry - Neurosurgery. Demographic and clinical data including occurrence of seizures were retrieved from the registry. The patients did not receive routine seizure prophylaxis. Univariate and multivariable logistic regression analyses were used to investigate risk factors associated with EPTS.
results103 of 1827 patients (5.6%) had new-onset seizures within the first week after TBI. The following factors were in multivariable analyses associated with EPTS; alcohol abuse (odds ratio [OR] 3.6, 95% CI 2.3-5.7, p < .001), moderate and severe brain injury (OR 2.2, 95% CI 1.3-3.8, p = .004 and OR 2.1, 95% CI 1.2-3.6, p = .012), brain contusion (OR 1.6, 95% CI 1.0-2.4, p = .046) and subdural hematoma (OR 1.6, 95% CI 1.0-2.6, p = .052).
conclusionIn our material, EPTS occurred in 5.6% of hospital-admitted TBI-patients. Alcohol abuse was the most significant risk factor, followed by moderate and severe brain injury. The results of this study contribute to the discussion about preventive treatment of EPTS in certain risk groups.
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