Evidence map›Paper›PMID 35833137›Full record

ArticleFrontiers in immunology2022

Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses.

Matthew Lacorcia, Réka Kugyelka, Lorenz Spechtenhauser, Ulrich Fabien Prodjinotho, Youssef Hamway, Thomas Spangenberg, Clarissa Prazeres da Costa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Matthew LacorciaTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Réka KugyelkaTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Lorenz SpechtenhauserTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Ulrich Fabien ProdjinothoTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Youssef HamwayTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Thomas SpangenbergGlobal Health Institute of Merck, Ares Trading S.A. (a subsidiary of Merck KGaA Darmstadt Germany), Eysins, Switzerland.
Clarissa Prazeres da CostaTechnical University of Munich (TUM), School of Medicine, Institute for Med. Microbiology, Immunology and Hygiene, Munich, Germany.
Technical University of Munich · DEMerck (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alongside the wide distribution throughout sub Saharan Africa of schistosomiasis, the morbidity associated with this chronic parasitic disease in endemic regions is often coupled with infection-driven immunomodulatory processes which modify inflammatory responses. Early life parasite exposure is theorized to drive immune tolerance towards cognate infection as well as bystander immune responses, beginning with

Indexed as

AnthelminticsSchistosomiasisAnimalsAntibody FormationCytokinesFemaleHumansMaternal MortalityMebendazoleMiceMorbidityPraziquantelPregnancySchistosomaAnthelminticsCytokinesMebendazolePraziquantelanthelminthicfetomaternal cross talkPraziquantel (PZQ)Schistosomiasistransgenerational immune priming

Identifiers

PMID35833137
PMCPMC9272909
OpenAlexW4285506101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.