Evidence map›Paper›PMID 35833131›Full record

ArticleFrontiers in immunology2022

IFNAR1 Deficiency Impairs Immunostimulatory Properties of Neutrophils in Tumor-Draining Lymph Nodes.

Timon Hussain, Maksim Domnich, Sharareh Bordbari, Ekaterina Pylaeva, Elena Siakaeva, Ilona Spyra, Irem Ozel, Freya Droege, Anthony Squire, Stefan Lienenklaus and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Tumor-educated cells in tumor microenvironment: Key drivers of immunotherapy resistance.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  4. Review
  5. Harnessing myeloid cells in cancer.Molecular cancer · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Timon HussainDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Maksim DomnichDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sharareh BordbariDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Ekaterina PylaevaDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Elena SiakaevaDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Ilona SpyraDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Irem OzelDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Freya DroegeDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Anthony SquireInstitute for Experimental Immunology and Imaging, University Duisburg-Essen, Essen, Germany.
Stefan LienenklausInstitute for Laboratory Animal Science, Institute of Immunology, Hannover Medical School, Hannover, Germany.
Kathrin SutterInstitute for Virology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Anja HasenbergInstitute for Experimental Immunology and Imaging, University Duisburg-Essen, Essen, Germany.
Matthias GunzerInstitute for Experimental Immunology and Imaging, University Duisburg-Essen, Essen, Germany.
Stephan LangDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jadwiga JablonskaDepartment of Otorhinolaryngology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DELeibniz Institute for Analytical Sciences - ISAS · DEMedizinische Hochschule Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-draining lymph nodes (TDLNs) are the first organs where the metastatic spread of different types of cancer, including head and neck cancer (HNC), occurs and have therefore high prognostic relevance. Moreover, first anti-cancer immune responses have been shown to be initiated in such LNs

Indexed as

Interferon Type INeoplasmsReceptor, Interferon alpha-betaAnimalsLymph NodesMiceNeutrophilsSignal TransductionTumor MicroenvironmentIfnar1 protein, mouseInterferon Type IReceptor, Interferon alpha-betaHNC (head and neck cancer)IFNAR1Interferonsintravital microscopyneutrophilsneutrophils/T-cells interactionstumor-draining lymph nodes

Identifiers

PMID35833131
PMCPMC9271705
OpenAlexW4283590203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.