ArticleFrontiers in neuroscience2022
Altered Functional Network Connectivity of Precuneus and Executive Control Networks in Type 2 Diabetes Mellitus Without Cognitive Impairment.
Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 9 citations in OpenAlex.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Investigating the application of IoT mobile app and healthcare services for diabetic elderly: A systematic review.PloS one · 2025Pooled it
- Altered Regional Brain Activity and Functional Connectivity Between Non-Diabetic and Diabetic Kidney Disease: A Resting-State fMRI Study.Brain and behavior · 2026Article
- Structural connectivity of hippocampus is not altered in patients with type 2 diabetes and without peripheral microangiopathy.Brain imaging and behavior · 2025Article
- Sleep habits, brain functional networks, and type 2 diabetes risk: cohort studies from North American and Asian populations and mediating Mendelian randomization analyses.Diabetology & metabolic syndrome · 2025Article
- Altered static and dynamic functional network connectivity in individuals with subthreshold depression: a large-scale resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- Article
- Association of individual-based morphological brain network alterations with cognitive impairment in type 2 diabetes mellitus.Frontiers in neurology · 2024Article
- Detecting type 2 diabetes mellitus cognitive impairment using whole-brain functional connectivity.Scientific reports · 2023Article
- Association between gene expression and altered resting-state functional networks in type 2 diabetes.Frontiers in aging neuroscience · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In epidemiological studies, type 2 diabetes mellitus (T2DM) has been associated with cognitive impairment and dementia, but studies about functional network connectivity in T2DM without cognitive impairment are limited. This study aimed to explore network connectivity alterations that may help enhance our understanding of damage-associated processes in T2DM. MRI data were analyzed from 82 patients with T2DM and 66 normal controls. Clinical, biochemical, and neuropsychological assessments were conducted in parallel with resting-state functional magnetic resonance imaging, and the cognitive status of the patients was assessed using the Montreal Cognitive Assessment-B (MoCA-B) score. Independent component analysis revealed a positive correlation between the salience network and the visual network and a negative connection between the left executive control network and the default mode network in patients with T2DM. The differences in dynamic brain network connectivity were observed in the precuneus, visual, and executive control networks. Internal network connectivity was primarily affected in the thalamus, inferior parietal lobe, and left precuneus. Hemoglobin A1c level, body mass index, MoCA-B score, and grooved pegboard (R) assessments indicated significant differences between the two groups (
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