Evidence map›Paper›PMID 35832865›Full record

ArticlePNAS nexus2022

Excess natural-cause deaths in California by cause and setting: March 2020 through February 2021.

Yea-Hung Chen, Andrew C Stokes, Hélène E Aschmann, Ruijia Chen, Shelley DeVost, Mathew V Kiang, Suneil Koliwad, Alicia R Riley, M Maria Glymour, Kirsten Bibbins-Domingo

Abstract read
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Excess natural-cause mortality in US counties and its association with reported COVID-19 deaths.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Dynamics of racial disparities in all-cause mortality during the COVID-19 pandemic.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. The impact of the SARS-CoV-2 pandemic on cause-specific mortality patterns: a systematic literature review.Zeitschrift fur Gesundheitswissenschaften = Journal of public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yea-Hung ChenDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-7949-0692
Andrew C StokesDepartment of Global Health, Boston University School of Public Health, Boston, MA 02118, USA.ORCID https://orcid.org/0000-0002-8502-3636
Hélène E AschmannDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0003-1234-4321
Ruijia ChenDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-2759-9290
Shelley DeVostDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.
Mathew V KiangDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Palo Alto, CA 94304, USA.ORCID https://orcid.org/0000-0001-9198-150X
Suneil KoliwadDepartment of Medicine, and Diabetes Center, University of California, San Francisco, CA 94117, USA.
Alicia R RileyDepartment of Sociology, University of California, Santa Cruz, CA 95064, USA.ORCID https://orcid.org/0000-0002-3341-6892
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.
Kirsten Bibbins-DomingoDepartment of Epidemiology and Biostatistics, University of California, 550 16th St, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-8962-0622

Funding

Translational Epidemiology - Training for Research on Aging and Chronic diseaseT32AG049663 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Elizabeth Rose Mayeda, Mark J Pletcher · 2016 to 2026
$5.8M
Reducing racial disparities in the treatment of opioid use disorder using machine learning-based causal analysisR00DA051534 · NIDA · STANFORD UNIVERSITY · PI KIANG, MATHEW VINHHOA · 2022 to 2024
$747k
NIA NIH HHS T32 AG049663NIDA NIH HHS R00 DA051534
6 · The paper itself

Abstract

Excess mortality has exceeded reported deaths from Covid-19 during the pandemic. This gap may be attributable to deaths that occurred among individuals with undiagnosed Covid-19 infections or indirect consequences of the pandemic response such as interruptions in medical care; distinguishing these possibilities has implications for public health responses. In the present study, we examined patterns of excess mortality over time and by setting (in-hospital or out-of-hospital) and cause of death using death certificate data from California. The estimated number of excess natural-cause deaths from 2020 March 1 to 2021 February 28 (69,182) exceeded the number of Covid-19 diagnosed deaths (53,667) by 29%. Nearly half, 47.4% (32,775), of excess natural-cause deaths occurred out of the hospital, where only 28.6% (9,366) of excess mortality was attributed to Covid-19. Over time, increases or decreases in excess natural non-Covid-19 mortality closely mirrored increases or decreases in Covid-19 mortality. The time series were positively correlated in out-of-hospital settings, particularly at time lags when excess natural-cause deaths preceded reported Covid-19 deaths; for example, when comparing Covid-19 deaths to excess natural-cause deaths in the week prior, the correlation was 0.73. The strong temporal association of reported Covid-19 deaths with excess out-of-hospital deaths from other reported natural-cause causes suggests Covid-19 deaths were undercounted during the first year of the pandemic.

Indexed as

cause of deathCovid-19excess mortalityhome deaths

Identifiers

PMID35832865
PMCPMC9272175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.