ArticleThe quarterly journal of economics2022
ORIGINS OF THE OPIOID CRISIS AND ITS ENDURING IMPACTS.
Article in The quarterly journal of economics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 4 citations in OpenAlex.
- Lessons From the Community-Engaged, Data-Driven Selection of Evidence-Based Practice Strategies in the HEALing Communities Study.Journal of public health management and practice : JPHMPTrial
- Understanding pharmaceutical industry coalitions: a case study of Mallinckrodt.Humanities & social sciences communications · 2026Article
- Commentary on Comstock et al.: Here we go again-Kratom and the failure to learn from the opioid crisis.Addiction (Abingdon, England) · 2026Article
- Stability and turbulence in illegal drug markets.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Multilingual analysis of public discourse on opioid and non-opioid analgesics through social media: a cross-sectional infodemiological study.BMC medical research methodology · 2026Article
- Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse.International journal of mental health nursing · 2026Review
- From addiction to aggression: The spillover effects of opioid policies on intimate partner violence.Journal of health economics · 2025Article
- What Drives Risky Prescription Opioid Use?: Evidence from Migration.The quarterly journal of economics · 2025Article
- Geography And Fentanyl: Explaining The Disproportionate Rise In Opioid Overdose Deaths Among Black Americans.Health affairs (Project Hope) · 2025Article
- Accountability in global health systems: insights from a network analysis of Purdue Pharmaceuticals.Globalization and health · 2025Article
- Article
- Global and regional burden of four drug use disorders in the elderly, 1990 to 2021: an analysis of the global burden of disease study.BMC geriatrics · 2025Article
- Differential Modulation of Glutamate Transporter-1 by Cocaine and Oxycodone and the Efficacy of MC-100093 to Reduce Reinstatement of Self-Administration.Brain and behavior · 2025Article
- Potentially Inappropriate Use of Transdermal Fentanyl in Working-Age and Older Adult Populations with Non-Cancer Pain: Nationwide Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Regular use of opioids and dementia, cognitive measures, and neuroimaging outcomes among UK Biobank participants with chronic non-cancer pain.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Optimization of Postoperative Opioids Use Following Spine Surgery.Current pain and headache reports · 2025Review
- Morphine-Induced Antinociception Is Potentiated and Dopamine Elevations Are Inhibited by the Biased Kappa Opioid Receptor Agonist Triazole 1.1.ACS chemical neuroscience · 2025Article
- Integrating Nursing Practice and Policy in Opioid Overdose Prevention: Analysis of the Opioid-Overdose Reduction Continuum of Care Approach Practice Guide.Journal of advanced nursing · 2025Article
- Fighting abuse with prescription tracking: mandatory drug monitoring and intimate partner violence.Journal of population economics · 2025Article
- Understanding the demographics of the opioid overdose death crisis.Journal of population economics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Overdose deaths involving opioids have increased dramatically since the 1990s, leading to the worst drug overdose epidemic in U.S. history, but there is limited empirical evidence about the initial causes. In this article, we examine the role of the 1996 introduction and marketing of OxyContin as a potential leading cause of the opioid crisis. We leverage cross-state variation in exposure to OxyContin's introduction due to a state policy that substantially limited the drug's early entry and marketing in select states. Recently unsealed court documents involving Purdue Pharma show that state-based triplicate prescription programs posed a major obstacle to sales of OxyContin and suggest that less marketing was targeted to states with these programs. We find that OxyContin distribution was more than 50% lower in "triplicate states" in the years after the drug's launch. Although triplicate states had higher rates of overdose deaths prior to 1996, this relationship flipped shortly after the launch and triplicate states saw substantially slower growth in overdose deaths, continuing even 20 years after OxyContin's introduction. Our results show that the introduction and marketing of OxyContin explain a substantial share of overdose deaths over the past two decades.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.