Evidence map›Paper›PMID 35832724›Full record

ReviewJournal of tissue engineering

Steering the multipotent mesenchymal cells towards an anti-inflammatory and osteogenic bias via photobiomodulation therapy: How to kill two birds with one stone.

Andrea Amaroli, Claudio Pasquale, Angelina Zekiy, Stefano Benedicenti, Andrea Marchegiani, Maria Giovanna Sabbieti, Dimitrios Agas

Open access · goldAbstract readReview
In one paragraph

Review in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Andrea AmaroliDepartment of Surgical and Diagnostic Sciences, University of Genoa, Genoa, Italy.
Claudio PasqualeDepartment of Surgical and Diagnostic Sciences, University of Genoa, Genoa, Italy.
Angelina ZekiyDepartment of Orthopedic Dentistry, Faculty of Dentistry, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Stefano BenedicentiDepartment of Surgical and Diagnostic Sciences, University of Genoa, Genoa, Italy.
Andrea MarchegianiSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino (MC), Italy.
Maria Giovanna SabbietiSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino (MC), Italy.
Dimitrios AgasSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino (MC), Italy.ORCID https://orcid.org/0000-0002-7809-3601
Università di Camerino · ITSechenov University · RUUniversity of Genoa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone marrow-derived multipotent mesenchymal cells (MSCs) have captured scientific interest due to their multi-purpose features and clinical applications. The operational dimension of MSCs is not limited to the bone marrow reservoir, which exerts bone-building and niche anabolic tasks; they also meet the needs of quenching inflammation and restoring inflamed tissues. Thus, the range of MSC activities extends to conditions such as neurodegenerative diseases, immune disorders and various forms of osteopenia. Steering these cells towards becoming an effective therapeutic tool has become mandatory. Many laboratories have employed distinct strategies to improve the plasticity and secretome of MSCs. We aimed to present how photobiomodulation therapy (PBM-t) can manipulate MSCs to render them an extraordinary anti-inflammatory and osteogenic instrument. Moreover, we discuss the outcomes of different PBM-t protocols on MSCs, concluding with some perplexities and complexities of PBM-t in vivo but encouraging and feasible in vitro solutions.

Indexed as

Bone marrow mesenchymal cellslight therapylow-level laser therapymesenchymal stem cell

Identifiers

PMID35832724
PMCPMC9272199
OpenAlexW4285206145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.