Evidence map›Paper›PMID 35832434›Full record

ArticleFrontiers in endocrinology2022

Primary Congenital Hypothyroidism in Children Below 3 Years Old - Etiology and Treatment With Overtreatment and Undertreatment Risks, a 5-Year Single Centre Experience.

Elżbieta Lipska, Agnieszka Lecka-Ambroziak, Daniel Witkowski, Katarzyna Szamotulska, Ewa Mierzejewska, Mariusz Ołtarzewski

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elżbieta LipskaEndocrinology Outpatient Clinic, Institute of Mother and Child, Warsaw, Poland.
Agnieszka Lecka-AmbroziakEndocrinology Outpatient Clinic, Institute of Mother and Child, Warsaw, Poland.
Daniel WitkowskiEndocrinology Outpatient Clinic, Institute of Mother and Child, Warsaw, Poland.
Katarzyna SzamotulskaDepartment of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.
Ewa MierzejewskaDepartment of Epidemiology and Biostatistics, Institute of Mother and Child, Warsaw, Poland.
Mariusz OłtarzewskiDepartment of Screening and Metabolic Diagnostics, Institute of Mother and Child, Warsaw, Poland.
Children's Memorial Health Institute · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Worldwide neonatal screening for congenital hypothyroidism (CH) is a gold standard of active surveillance in newborns. Prompt diagnosis, subsequent timely treatment implementation, and proper dosage of levothyroxine (L-T4) are crucial for normal growth and development, especially of the central nervous system. However, overtreatment may have a potential negative impact on further neurodevelopment. We retrospectively analysed data of 99 newborns with CH diagnosis, referred to the Endocrinology Outpatient Clinic of the Institute of Mother and Child in Warsaw, Poland from the CH screening program from 2017 to 2021. We evaluated the diagnostic process and treatment up to the age of 3 years. We compared groups of children from the first and the second screening groups (FSG, SSG) in the neonatal screening with an evaluation of ultrasound examination (thyroid dysgenesis vs. gland

Indexed as

Congenital HypothyroidismThyroid DysgenesisChildChild, PreschoolHumansInfant, NewbornNeonatal ScreeningOvertreatmentRetrospective StudiesThyrotropinThyroxineThyrotropinThyroxineCH overtreatmentCH undertreatmentcongenital hypothyroidismneonatal screeningneurodevelopmentpermanent CHtransient CHTSH threshold

Identifiers

PMID35832434
PMCPMC9271568
OpenAlexW4283582183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.