Evidence map›Paper›PMID 35832429›Full record

ArticleFrontiers in endocrinology2022

Minimizing Mitogenic Potency of Insulin Analogues Through Modification of a Disulfide Bond.

Shee Chee Ong, Alessia Belgi, Allanah L Merriman, Carlie A Delaine, Bianca van Lierop, Sofianos Andrikopoulos, Andrea J Robinson, Briony E Forbes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Shee Chee OngDiscipline of Medical Biochemistry, Flinders Health and Medical Research Institute, Flinders University of South Australia, Bedford Park, SA, Australia.
Alessia BelgiSchool of Chemistry, Monash University, Clayton, VIC, Australia.
Allanah L MerrimanDiscipline of Medical Biochemistry, Flinders Health and Medical Research Institute, Flinders University of South Australia, Bedford Park, SA, Australia.
Carlie A DelaineDiscipline of Medical Biochemistry, Flinders Health and Medical Research Institute, Flinders University of South Australia, Bedford Park, SA, Australia.
Bianca van LieropSchool of Chemistry, Monash University, Clayton, VIC, Australia.
Sofianos AndrikopoulosDepartment of Medicine, University of Melbourne, Parkville, VIC, Australia.
Andrea J RobinsonSchool of Chemistry, Monash University, Clayton, VIC, Australia.
Briony E ForbesDiscipline of Medical Biochemistry, Flinders Health and Medical Research Institute, Flinders University of South Australia, Bedford Park, SA, Australia.
Flinders University · AUMonash University · AUUniversity of Melbourne · AUUniversity of South Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms by which insulin activates the insulin receptor to promote metabolic processes and cellular growth are still not clear. Significant advances have been gained from recent structural studies in understanding how insulin binds to its receptor. However, the way in which specific interactions lead to either metabolic or mitogenic signalling remains unknown. Currently there are only a few examples of insulin receptor agonists that have biased signalling properties. Here we use novel insulin analogues that differ only in the chemical composition at the A6-A11 bond, as it has been changed to a rigid, non-reducible C=C linkage (dicarba bond), to reveal mechanisms underlying signaling bias. We show that introduction of an A6-A11

Indexed as

InsulinReceptor, InsulinDisulfidesIntercellular Signaling Peptides and ProteinsMitogensReceptor, IGF Type 1DisulfidesInsulinIntercellular Signaling Peptides and ProteinsMitogensReceptor, IGF Type 1Receptor, Insulinbiased signalling agonistscell signallingdicarba insulinextracellular-signal-regulated kinase (ERK)glucose metabolisminsulininsulin receptormitogenic

Identifiers

PMID35832429
PMCPMC9271792
OpenAlexW4283581289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.