Evidence map›Paper›PMID 35832412›Full record

ArticleFrontiers in bioengineering and biotechnology2022

Stem Cell Fate and Immunomodulation Promote Bone Regeneration

Maria Rosa Iaquinta, Fernanda Martini, Antonio D'Agostino, Lorenzo Trevisiol, Massimo Bersani, Elena Torreggiani, Mauro Tognon, John Charles Rotondo, Elisa Mazzoni

Open access · goldAbstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Bio-OssFrontiers in bioengineering and biotechnology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Revolutionizing bone healing: the role of 3D models.Cell regeneration (London, England) · 2025
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Maria Rosa IaquintaDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Fernanda MartiniDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Antonio D'AgostinoDepartment of Surgery, University of Verona, Verona, Italy.
Lorenzo TrevisiolDepartment of Surgery, University of Verona, Verona, Italy.
Massimo BersaniDepartment of Surgery, University of Verona, Verona, Italy.
Elena TorreggianiDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Mauro TognonDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
John Charles RotondoDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Elisa MazzoniDepartment of Chemistry, Pharmaceutical and Agricultural Sciences, University of Ferrara, Ferrara, Italy.
University of Ferrara · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects in maxillofacial regions lead to noticeable deformity and dysfunctions. Therefore, the use of biomaterials/scaffolds for maxillofacial bone regrowth has been attracting great interest from many surgical specialties and experts. Many approaches have been devised in order to create an optimal bone scaffold capable of achieving desirable degrees of bone integration and osteogenesis. Osteogenesis represents a complex physiological process involving multiple cooperating systems. A tight relationship between the immune and skeletal systems has lately been established using the concept of "osteoimmunology," since various molecules, particularly those regulating immunological and inflammatory processes, are shared. Inflammatory mediators are now being implicated in bone remodeling, according to new scientific data. In this study, a profiler PCR array was employed to evaluate the expression of cytokines and chemokines in human adipose derived-mesenchymal stem cells (hASCs) cultured on porous hydroxylapatite (HA)/Collagen derived Bio-Oss

Indexed as

biomaterialchemokinecytokineimmunomodulationosteogenic differentiationstem cells

Identifiers

PMID35832412
PMCPMC9271820
OpenAlexW4283593027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.