Evidence map›Paper›PMID 35832397›Full record

ArticleFrontiers in molecular neuroscience2022

Nedd4-2 Haploinsufficiency in Mice Impairs the Ubiquitination of Rer1 and Increases the Susceptibility to Endoplasmic Reticulum Stress and Seizures.

Xiaoliang Liu, Lu Zhang, Hebo Zhang, Xiaoyan Liang, Bijun Zhang, Jianqiao Tu, Yanyan Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Voltage-Gated NaLife (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaoliang LiuDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Lu ZhangDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Hebo ZhangDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Xiaoyan LiangDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Bijun ZhangDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Jianqiao TuDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
Yanyan ZhaoDepartment of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, China.
China Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4-2) is an epilepsy-associated gene encoding an E3 ligase that ubiquitinates neuroactive substrates. An involvement of NEDD4-2 in endoplasmic reticulum (ER) stress has been recently found with mechanisms needing further investigations. Herein,

Indexed as

epilepsyNEDD4Lretention in endoplasmic reticulum 1stressubiquitination

Identifiers

PMID35832397
PMCPMC9271913
OpenAlexW4283576813

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.