ReviewJournal of engineering and science in medical diagnostics and therapy2022
Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.
Review in Journal of engineering and science in medical diagnostics and therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Can measures of small airway dysfunction aid with the diagnosis or management of asthma exacerbations? A systematic review.BMJ open respiratory research · 2025Pooled it
- Quantitative assessment of lung mechanical properties in ARDS using X-ray computed tomography.Intensive care medicine experimental · 2026Review
- A multi-fidelity poroelastic finite element and machine learning framework for characterizing respiratory mechanics in porcine lungs.Biomechanics and modeling in mechanobiology · 2026Article
- A Simulation-Based Mechanical System-Identification Framework for Non-Invasive Lung Diagnostics and Personalized Pulmonary Rehabilitation.Life (Basel, Switzerland) · 2026Article
- Beyond One-Size-Fits-All: Precision Mechanical Ventilation in ARDS.Journal of clinical medicine · 2026Review
- Percolation Forces in Lung Inflammation: Determining the Path to Emphysema or Fibrosis.Biomedicines · 2026Review
- Artificial intelligence-assisted multiscale lung modeling to predict alveolar septal wall stress.Acta biomaterialia · 2026Article
- Interactive effects of pulmonary pathologies and ventilation modes driving heterogeneous and anisotropic regional strain mechanics.Scientific reports · 2025Article
- Physics-Informed In-Silico Dynamic Computed Tomography of Human Lungs: Generation, Evaluation, and Refinement.Journal of biomechanical engineering · 2025Article
- Structural and functional characteristics of healthy and injured porcine lungs during deflation: a quantitative CT imaging analysis.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Letter to the Editor: An unspoken contributor to VILI in ARDS-asymmetry of lung injury.Intensive care medicine · 2025Article
- Forward Computational Modeling of Respiratory Airflow.Applied sciences (Basel, Switzerland) · 2024Article
- Imaging the Lung in ARDS: A Primer.Respiratory care · 2024Review
- Article
- In-silico CT lung phantom generated from finite-element mesh.Proceedings of SPIE--the International Society for Optical Engineering · 2024Article
- A scale-free model of acute and ventilator-induced lung injury: a network theory approach inspired by seismology.Frontiers in network physiology · 2024Article
- Editorial: Understanding the impact of lung ventilation heterogeneity.Frontiers in medical technology · 2024Article
- Management of refractory hypoxemia using recruitment maneuvers and rescue therapies: A comprehensive review.Frontiers in veterinary science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian lung is characterized by heterogeneity in both its structure and function, by incorporating an asymmetric branching airway tree optimized for maintenance of efficient ventilation, perfusion, and gas exchange. Despite potential benefits of naturally occurring heterogeneity in the lungs, there may also be detrimental effects arising from pathologic processes, which may result in deficiencies in gas transport and exchange. Regardless of etiology, pathologic heterogeneity results in the maldistribution of regional ventilation and perfusion, impairments in gas exchange, and increased work of breathing. In extreme situations, heterogeneity may result in respiratory failure, necessitating support with a mechanical ventilator. This review will present a summary of measurement techniques for assessing and quantifying heterogeneity in respiratory system structure and function during mechanical ventilation. These methods have been grouped according to four broad categories: (1) inverse modeling of heterogeneous mechanical function; (2) capnography and washout techniques to measure heterogeneity of gas transport; (3) measurements of heterogeneous deformation on the surface of the lung; and finally (4) imaging techniques used to observe spatially-distributed ventilation or regional deformation. Each technique varies with regard to spatial and temporal resolution, degrees of invasiveness, risks posed to patients, as well as suitability for clinical implementation. Nonetheless, each technique provides a unique perspective on the manifestations and consequences of mechanical heterogeneity in the diseased lung.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.