Evidence map›Paper›PMID 35832079›Full record

ArticleTheranostics2022

Specific (sialyl-)Lewis core 2

Katarina Madunić, Oleg A Mayboroda, Tao Zhang, Julia Weber, Geert-Jan Boons, Hans Morreau, Ronald van Vlierberghe, Tom van Wezel, Guinevere S M Lageveen-Kammeijer, Manfred Wuhrer

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 46 citations in OpenAlex.

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  15. ComprehensiveAnalytical chemistry · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Katarina MadunićLeiden University Medical Center, Center for Proteomics and Metabolomics, Postbus 9600, 2300 RC Leiden, The Netherlands.
Oleg A MayborodaLeiden University Medical Center, Center for Proteomics and Metabolomics, Postbus 9600, 2300 RC Leiden, The Netherlands.
Tao ZhangLeiden University Medical Center, Center for Proteomics and Metabolomics, Postbus 9600, 2300 RC Leiden, The Netherlands.
Julia WeberDepartment of Chemical Biology and Drug Discovery, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Geert-Jan BoonsDepartment of Chemical Biology and Drug Discovery, Utrecht University, Universiteitsweg 99, 3584 CG Utrecht, The Netherlands.
Hans MorreauLeiden University Medical Center, Department of Pathology, Postbus 9600, 2300 RC Leiden, The Netherlands.
Ronald van VlierbergheLeiden University Medical Center, Department of Surgery, Postbus 9600, 2300 RC Leiden, The Netherlands.
Tom van WezelLeiden University Medical Center, Department of Pathology, Postbus 9600, 2300 RC Leiden, The Netherlands.
Guinevere S M Lageveen-KammeijerLeiden University Medical Center, Center for Proteomics and Metabolomics, Postbus 9600, 2300 RC Leiden, The Netherlands.
Manfred WuhrerLeiden University Medical Center, Center for Proteomics and Metabolomics, Postbus 9600, 2300 RC Leiden, The Netherlands.
Leiden University Medical Center · NLNetherlands Metabolomics Centre · NL

Funding

Austrian Science Fund FWF J 4260
6 · The paper itself

Abstract

Cells are covered with a dense layer of carbohydrates, some of which are solely present on neoplastic cells. The so-called tumor-associated carbohydrate antigens (TACAs) are increasingly recognized as promising targets for immunotherapy. These carbohydrates differ from those of the surrounding non-cancerous tissues and contribute to the malignant phenotype of the cancer cells by promoting proliferation, metastasis, and immunosuppression. However, due to tumor tissue heterogeneity and technological limitations, TACAs are insufficiently explored.

Indexed as

Colorectal NeoplasmsPolysaccharidesAntigens, Tumor-Associated, CarbohydrateCarbohydratesEpitheliumHumansAntigens, Tumor-Associated, CarbohydrateCarbohydratesPolysaccharidesglycomicsmass spectrometrytherapeutic targetTumor associated carbohydrate antigens (TACAs)

Identifiers

PMID35832079
PMCPMC9254241
OpenAlexW4285253926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.