ArticleThe New phytologist2022
Histone acetyltransferase TaHAG1 interacts with TaPLATZ5 to activate TaPAD4 expression and positively contributes to powdery mildew resistance in wheat.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Genome-Wide Characterization of theBiology · 2026Article
- Effector FpECIR from Fusarium pseudograminearum targets wheat ethylene signaling pathway to suppress plant immunity.Stress biology · 2026Article
- Genomic and genetic dissection of drought tolerance in a resilient wheat germplasm JIN50.Nature genetics · 2026Article
- Lily Transcription Factors LlPLATZ1 and LlMYB4 Orchestrate the Homeostasis of Heat Stress Responses via Antagonistic Regulation of LlHSF24.Plant biotechnology journal · 2026Article
- Wheat SWI3B Subunit of SWI/SNF Chromatin Remodeling Complex Governs Powdery Mildew Susceptibility by Suppressing Salicylic Acid Biosynthesis.Journal of fungi (Basel, Switzerland) · 2026Article
- Wheat DNA Methyltransferase TaMET1 Negatively Regulates Salicylic Acid Biosynthesis to Facilitate Powdery Mildew Susceptibility.Journal of fungi (Basel, Switzerland) · 2025Article
- Chromatin Remodeler TaSWI3D Controls Wheat Susceptibility to Pathogenic FungusMicroorganisms · 2025Article
- TaIRE1-mediated unconventional splicing of the TabZIP60 mRNA and the miR172 precursor regulates heat stress tolerance in wheat.Journal of integrative plant biology · 2025Article
- Lysine deacetylase TaSRT1 mediates wheat drought tolerance by deacetylating TaDT-A to reduce its protein stability and transcriptional activity.Plant biotechnology journal · 2025Article
- CitGATA7 interact with histone acetyltransferase CitHAG28 to promote citric acid degradation by regulating the glutamine synthetase pathway in citrus.Molecular horticulture · 2025Article
- Phytoalexin deficient 4 is associated with the lesion mimic trait in watermelon clalm mutant (Citrullus lanatus).BMC plant biology · 2025Article
- Antioxidant Responses and Redox Regulation Within Plant-Beneficial Microbe Interaction.Antioxidants (Basel, Switzerland) · 2024Review
- The transcription factor CAMTA2 interacts with the histone acetyltransferase GCN5 and regulates grain weight in wheat.The Plant cell · 2024Article
- From histone acetylation to abundance: The role of GCN5-CAMTA2 interaction in wheat grain weight.The Plant cell · 2024Article
- Research Progress on the Mechanism and Function of Histone Acetylation Regulating the Interaction between Pathogenic Fungi and Plant Hosts.Journal of fungi (Basel, Switzerland) · 2024Review
- Methyltransferase TaSAMT1 mediates wheat freezing tolerance by integrating brassinosteroid and salicylic acid signaling.The Plant cell · 2024Article
- ZmELP1, an Elongator complex subunit, is required for the maintenance of histone acetylation and RNA Pol II phosphorylation in maize kernels.Plant biotechnology journal · 2024Article
- Epigenetic weapons of plants against fungal pathogens.BMC plant biology · 2024Review
- Regulation of Disease-Resistance Genes against CWMV Infection by NbHAG1-Mediated H3K36ac.International journal of molecular sciences · 2024Article
- Review
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
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Abstract
Plants have evolved a two-branched innate immune system to detect and cope with pathogen attack, which are initiated by cell-surface and intracellular immune receptors leading to pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), respectively. A core transducer including PAD4-EDS1 node is proposed as the convergence point for a two-tiered immune system in conferring pathogen immunity. However, the transcriptional regulatory mechanisms controlling expression of these key transducers remain largely unknown. Here, we identified histone acetyltransferase TaHAG1 as a positive regulator of powdery mildew resistance in wheat. TaHAG1 regulates expression of key transducer gene TaPAD4 and promotes SA and reactive oxygen species accumulation to accomplish resistance to Bgt infection. Moreover, overexpression and CRISPR-mediated knockout of TaPAD4 validate its role in wheat powdery mildew resistance. Furthermore, TaHAG1 physically interacts with TaPLATZ5, a plant-specific zinc-binding protein. TaPLATZ5 directly binds to promoter of TaPAD4 and together with TaHAG1 to potentiate the expression of TaPAD4 by increasing the levels of H3 acetylation. Our study revealed a key transcription regulatory node in which TaHAG1 acts as an epigenetic modulator and interacts with TaPLATZ5 that confers powdery mildew resistance in wheat through activating a convergence point gene between PTI and ETI, which could be effective for genetic improvement of disease resistance in wheat and other crops.
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