ArticleMicrobiome2022
The developing airway and gut microbiota in early life is influenced by age of older siblings.
Article in Microbiome, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Sibling factors associated with gut microbiota and fecal short-chain fatty acids in preschoolers.Pediatric research · 2026Article
- Early life bacteria and sibling exposure associate with restoration of the infant gut microbiome after cesarean section.Nature communications · 2026Article
- Article
- Early-life colonization by aromatic-lactate-producing bifidobacteria lowers the risk of allergic sensitization.Nature microbiology · 2026Article
- Off to a good start: current gaps and priorities in early-life microbiome research.FEMS microbiology reviews · 2026Review
- Pathogenesis of various pulmonary diseases by tuning immune response: insight from host-microbial crosstalk.Current research in microbial sciences · 2026Review
- The gut-lung axis in childhood asthma: from early-life programming to microbiome-informed precision medicine-a narrative review.Frontiers in immunology · 2026Review
- Causal effects of the gut microbiota, circulating metabolites, and cardiometabolic diseases: A Mendelian randomization study.Medicine · 2025Article
- Infant gut anellovirus composition associates with early life factors and childhood atopic disease.Nature communications · 2025Article
- The influence of early life exposures on the infant gut virome.Gut microbes · 2025Article
- The role of the early-life gut microbiome in childhood asthma.Gut microbes · 2025Review
- Major gut microbiota perturbations in firstborn infants compared to those with older siblings soon after delivery.BMC pediatrics · 2025Article
- The Home as a Modulator of Milk Immunity: Association Between Domestic Factors and Immune Cell Populations in Human Breast Milk.Nutrients · 2025Article
- Comparison of nasal microbiota between preterm and full-term infants in early life.Pediatric research · 2025Article
- Management of Neonates in the Special Care Nursery and Its Impact on the Developing Gut Microbiota: A Comprehensive Clinical Review.Microorganisms · 2025Review
- Transmission of the human respiratory microbiome and antibiotic resistance genes in healthy populations.Microbiome · 2025Article
- Prophages in the infant gut are pervasively induced and may modulate the functionality of their hosts.NPJ biofilms and microbiomes · 2025Article
- Infant Gut Microbiota and Childhood Blood Pressure: Prospective Associations and the Modifying Role of Breastfeeding.Journal of the American Heart Association · 2025Article
- Post-viral lung diseases: the microbiota as a key player.ERJ open research · 2025Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing up with siblings has been linked to numerous health outcomes and is also an important determinant for the developing microbiota. Nonetheless, research into the role of having siblings on the developing microbiota has mainly been incidental.
resultsHere, we investigate the specific effects of having siblings on the developing airway and gut microbiota using a total of 4497 hypopharyngeal and fecal samples taken from 686 children in the COPSAC
conclusionsHaving siblings is one of the most important factors influencing a child's developing microbiota, and the specific effects may explain previously established associations between siblings and asthma and infectious diseases. As such, siblings should be considered in all studies involving the developing microbiota, with emphasis on the age gap to the closest older sibling rather than the number of siblings. Video abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.