Evidence map›Paper›PMID 35831736›Full record

Trial reportInflammopharmacology2022

Effect of aqueous extract of seed of broccoli on inflammatory cytokines and Helicobacter pylori infection: a randomized, double-blind, controlled trial in patients without atrophic gastritis.

Kai Guo, Lei Wang, Jinli Mahe, Liansheng Li, Shaojiang Jiao, Haiyan Wang, Yanru Xie, Xiaoming Liu, Xuejiao Zeng, Xiaobin Hu and 1 more

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Inflammopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Beyond Antibiotics: Alternative Strategies TargetingExpert reviews in molecular medicine · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Kai Guo *Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Lei Wang *Department of Neurology, Lanzhou University Second Hospital, Lanzhou, Gansu Province, China.
Jinli Mahe *Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Liansheng LiJing Yuan County Hospital of Traditional Chinese Medicine, Baiyin, Gansu Province, China.
Shaojiang JiaoBai Yin Third People's Hospital, Baiyin, Gansu Province, China.
Haiyan WangBai Yin Third People's Hospital, Baiyin, Gansu Province, China.
Yanru XieInstitute of Nutrition and Health, BYHEALTH, Guangzhou, Guangdong Province, China.
Xiaoming LiuInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Xuejiao ZengInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Xiaobin HuInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China. huxiaobin@lzu.edu.cn.
Lipeng JingInstitute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China. jinglp@lzu.edu.cn.ORCID http://orcid.org/0000-0003-1856-0324
Lanzhou University · CNLanzhou University Second Hospital · CN

Funding

BYHEALTH TY0191115Cuiying Science and Technology Innovation Project of Lanzhou University Second Hospital CY-2019-QN19Fundamental Research Funds for the Central Universities lzujbky-2019-4Gansu Province Science Foundation for Youths 21JR7RA507
6 · The paper itself

Abstract

The purpose of this study was to investigate the anti-inflammatory effect of an aqueous extract of seed of broccoli (AESB) in Helicobacter pylori (HP)-infected patients without atrophic gastritis. This was a double-centre, randomized, double-blind, controlled study. A total of 110 HP-infected subjects were randomized to receive either AESB or placebo for 2 months. Inflammatory cytokine (IL-8, IFN-γ, TNF-α, CRP, IL-17A, IL-1β, IL-18), pepsinogen I, II (PG I, PG II), and gastrin-17 (G-17) measurements and

Indexed as

BrassicaGastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriAnti-Inflammatory AgentsCytokinesGastrinsHumansInterleukin-17Interleukin-18Interleukin-8Pepsinogen ATumor Necrosis Factor-alphaUreaAnti-Inflammatory AgentsCytokinesGastrinsInterleukin-17Interleukin-18Interleukin-8Pepsinogen ATumor Necrosis Factor-alphaUreaAqueous extract of seed of broccoliAtrophic gastritisHelicobacter pyloriInflammatory cytokinesPepsinogen

Identifiers

PMID35831736
OpenAlexW4285392084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.