Evidence map›Paper›PMID 35831726›Full record

ArticleArchives of microbiology2022

Assessment of free radicals and reactive oxygen species milieu in nanoparticles adjuvanted outer membrane proteins vaccine against Salmonella typhi.

Yashpal Singh, Amit Kumar, Anjani Saxena, Pankaj Bhatt, S P Singh, Avadhesh Kumar, Meena Mrigesh, Mumtesh Kumar Saxena

Abstract read
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In one paragraph

Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yashpal SinghDepartment of Molecular Biology and Genetic Engineering, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Amit KumarDivision of Animal Biotechnology, College of Biotechnology, Sardar Vallabh Bhai Patel University of Agriculture and Technology, Meerut, Uttar Pradesh, 250110, India.
Anjani SaxenaDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Pankaj BhattDepartment of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, 47906, USA.
S P SinghDepartment of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Avadhesh KumarDepartment of Veterinary and Animal Husbandry Extension Education, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Meena MrigeshDepartment of Veterinary Anatomy, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India.
Mumtesh Kumar SaxenaDepartment of Animal Genetics and Breeding, College of Veterinary and Animal Sciences, G.B. Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, 263145, India. mumteshsaxena@gmail.com.ORCID http://orcid.org/0000-0002-4657-4064
Govind Ballabh Pant University of Agriculture and Technology · INPurdue University West Lafayette · US

Funding

Department of Biotechnology, Government of West Bengal BT/PR796/ADV/116/2011
6 · The paper itself

Abstract

In this study, calcium phosphate nanoparticles-based (STCNV) and montanide oil adjuvant vaccine (STOAV) containing outer membrane proteins (Omps) of S. Typhi were evaluated for inducing oxidative stress indicators [reduced glutathione (GSH), lipid peroxidation (LPO), catalase, superoxide dismutase (SOD), and total protein] in the tissues of mice after vaccination. The GSH levels though slightly high in the liver, kidney, and lungs of STCNV group were not significantly different from STOAV and the control group (STC). There was no significant difference in LPO levels in any group for any tissue. The significantly lower activities of catalase were observed in the kidney and lungs of the STCNV group as compared to STOAV and STC group, while in the liver, STCNV group revealed lower catalase activity in comparison to the control group. No significant difference in the SOD activities between the two vaccinated groups was observed. The total protein contents in all the organs showed no significant difference in the vaccinated and the control group. The vaccines may induce long-term inflammatory response and consequently damage vital organs; this study revealed no long-term oxidative stress in all the three vital organs, suggesting that these vaccines may not cause oxidative damages in the vital organs of mice.

Indexed as

NanoparticlesVaccinesAdjuvants, ImmunologicAnimalsAntioxidantsCatalaseGlutathioneMembrane ProteinsMiceMineral OilOxidative StressReactive Oxygen SpeciesSalmonella typhiSuperoxide DismutaseAdjuvants, ImmunologicAntioxidantsCatalaseGlutathioneMembrane ProteinsMineral OilMonatide (IMS 3015)Reactive Oxygen SpeciesSuperoxide DismutaseVaccinesCalcium phosphate nanoparticlesOxidative stressSalmonella TyphiVaccine

Identifiers

PMID35831726
OpenAlexW4285087237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.