Evidence map›Paper›PMID 35831667›Full record

ReviewEuropean journal of nutrition2022

Effect of curcumin supplementation on exercise-induced muscle damage: a narrative review.

K Nanavati, K Rutherfurd-Markwick, S J Lee, N C Bishop, A Ali

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Muscle loss and GLP-1R agonists use.Acta diabetologica · 2026
    Review
  9. Review
  10. Therapeutic Potential of Plant Phenolic Acids Combating Cancer Drug Resistance.Recent advances in food, nutrition & agriculture · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

K NanavatiSchool of Sport, Exercise, and Nutrition, Massey University, Auckland, New Zealand.ORCID http://orcid.org/0000-0001-8638-3185
K Rutherfurd-MarkwickSchool of Health Sciences, Massey University, Auckland, New Zealand.ORCID http://orcid.org/0000-0002-8815-3786
S J LeeSchool of Food and Advanced Technology, Massey University, Auckland, New Zealand.ORCID http://orcid.org/0000-0003-0634-1984
N C BishopSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.ORCID http://orcid.org/0000-0001-6221-3907
A AliSchool of Sport, Exercise, and Nutrition, Massey University, Auckland, New Zealand. a.ali@massey.ac.nz.ORCID http://orcid.org/0000-0002-6093-1435
Massey University · NZLoughborough University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Curcumin, a natural polyphenol extracted from turmeric, is a potent antioxidant and anti-inflammatory agent. In the past few decades, curcumin's ability to impact chronic inflammatory conditions such as metabolic syndrome, arthritis, and cancer has been widely researched, along with growing interest in understanding its role in exercise-induced muscle damage (EIMD). EIMD impacts individuals differently depending on the type (resistance exercise, high-intensity interval training, and running), intensity, and duration of the exercise. Exercise disrupts the muscles' ultrastructure, raises inflammatory cytokine levels, and can cause swelling in the affected limb, a reduction in range of motion (ROM), and a reduction in muscular force-producing capacity. This review focuses on the metabolism, pharmacokinetics of various brands of curcumin supplements, and the effect of curcumin supplementation on EIMD regarding muscle soreness, activity of creatine kinase (CK), and production of inflammatory markers. Curcumin supplementation in the dose range of 90-5000 mg/day can decrease the subjective perception of muscle pain intensity, increase antioxidant capacity, and reduce CK activity, which reduces muscle damage when consumed close to exercise. Consumption of curcumin also improves muscle performance and has an anti-inflammatory effect, downregulating the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-8. Curcumin may also improve oxidative capacity without hampering training adaptations in untrained and recreationally active individuals. The optimal curcumin dose to ameliorate EIMD is challenging to assess as its effect depends on the curcumin concentration in the supplement and its bioavailability.

Indexed as

CurcuminDietary SupplementsExerciseMyalgiaAnti-Inflammatory AgentsAntioxidantsCreatine KinaseCytokinesHumansInterleukin-6Interleukin-8Muscle, SkeletalPolyphenolsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsCreatine KinaseCurcuminCytokinesInterleukin-6Interleukin-8PolyphenolsTumor Necrosis Factor-alphaAntioxidantCurcuminInflammationMuscle sorenessOxidative stressPharmacokinetics

Identifiers

PMID35831667
PMCPMC9596560
OpenAlexW4285394203

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.