Evidence map›Paper›PMID 35831632›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

High serum total cholesterol associated with good outcome in endovascular thrombectomy for acute large artery occlusion.

Sang Hee Ha, Jae-Chan Ryu, Jae-Han Bae, Sujin Koo, Boseong Kwon, Yunsun Song, Deok Hee Lee, Jun Young Chang, Dong-Wha Kang, Sun U Kwon and 2 more

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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sang Hee HaDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Jae-Chan RyuDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Jae-Han BaeDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Sujin KooGraduate School of Converging Clinical and Public Health, Ewha Womans University, Seoul, South Korea.
Boseong KwonDepartment of Radiology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Yunsun SongDepartment of Radiology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Deok Hee LeeDepartment of Radiology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Jun Young ChangDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Dong-Wha KangDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Sun U KwonDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Jong S KimDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea.
Bum Joon KimDepartment of Neurology, Asan Medical Center, University of Ulsan, Seoul, South Korea. medicj80@hanmail.net.ORCID http://orcid.org/0000-0002-3278-3252
Asan Medical Center · KREwha Womans University · KR

Funding

Ministry of Science and ICT, South Korea 2020R1A2C2100077National Foundation for Medical Research and Innovation 2020M3E5D2A01084576
6 · The paper itself

Abstract

backgroundThe effect of cholesterol on the functional outcome after endovascular thrombectomy (EVT) is still controversial. This study aimed to investigate whether the lipid profile is associated with the EVT prognosis.

methodsWe retrospectively analyzed patients with emergent large vessel occlusion who underwent EVT. The blood lipid levels were measured in the fasting state, 1 day after admission. We divided patients into terciles of serum total cholesterol (TC) levels and compared the clinical characteristics among the groups. The factors associated with a good outcome at 3 months (modified Rankin scale 0-2) were investigated, considering the stroke mechanism and recanalization status.

resultsAmong 274 patients, good outcomes were observed in 108 (39.4%) patients. Low initial severity (odds ratio (OR), 0.91, 95% confidence interval (CI), 0.858-0.954; p < 0.001) and high TC level (1.35, 1.034-1.758; p = 0.041) were associated with good outcomes. In patients with cardioembolism, young age (0.95, 0.915-0.991; p = 0.021), low initial severity (0.92, 0.857-0.988; p = 0.024), and high TC level (1.60, 1.019-2.499; p = 0.036) were associated with good outcomes. The lipid profile was not associated with a functional outcome in those with large artery atherosclerosis. In patients with complete recanalization, young age (0.97, 0.941-0.994; p = 0.016), low initial severity (0.91, 0.864-0.961; p = 0.001), absence of diabetes (0.45, 0.218-0.947; p = 0.035) or any hemorrhage (0.33, 0.142-0.760; p = 0.009), and high TC level (1.40, 1.031-1.879; p = 0.031) were associated with good outcomes.

conclusionsA high TC level was associated with favorable outcomes after EVT, especially in patients with cardioembolism and complete recanalization.

Indexed as

Brain IschemiaEndovascular ProceduresStrokeArteriesHumansLipidsRetrospective StudiesThrombectomyTreatment OutcomeLipidsEndovascular thrombectomyFunctional outcomeLipid profilesStroke mechanisms

Identifiers

PMID35831632
OpenAlexW4285393544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.