Evidence map›Paper›PMID 35831516›Full record

ArticleNatural products and bioprospecting2022

Cyclic heptapeptides with metal binding properties isolated from the fungus Cadophora malorum from Antarctic soil.

Guidmar C Donalle, María Martha Martorell, Gastón E Siless, Lucas Ruberto, Gabriela M Cabrera

Open access · diamondAbstract read
In one paragraph

Article in Natural products and bioprospecting, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guidmar C Donalle *Facultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Buenos Aires, Argentina.
María Martha Martorell *Instituto Antártico Argentino, Instituto Nanobiotec, CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina.
Gastón E SilessFacultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Buenos Aires, Argentina.
Lucas RubertoInstituto Antártico Argentino, Instituto Nanobiotec, CONICET-Universidad de Buenos Aires, Buenos Aires, Argentina. luruberto@gmail.com.
Gabriela M CabreraFacultad de Ciencias Exactas y Naturales, Departamento de Química Orgánica, Universidad de Buenos Aires, Buenos Aires, Argentina. gabyc@qo.fcen.uba.ar.ORCID http://orcid.org/0000-0002-4219-2026
Consejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación PICT 2018-0930Consejo Nacional de Investigaciones Científicas y Técnicas 112 20200101898Fondo para la Investigación Científica y Tecnológica PICT E 2018-0031Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires PDE-48-2020Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires UBACYT 2018-100246
6 · The paper itself

Abstract

The Antarctic fungus Cadophora malorum produces previously undescribed cyclic heptapeptides (cadophorin A and B) containing an anthranilic acid residue. The planar structure of these peptides was determined by high-resolution mass spectrometry combined with extensive 1D and 2D NMR spectroscopy. The absolute configuration of the amino acids was determined by Marfey's method, with HPLC analysis of FDVA (Nα-(2,4-dinitro-5-fluorphenyl)-L-valinamide) derivatives making use of a PFP column. Remarkably, cadophorin 2 possesses both the uncommon D-Ile and D-allo-Ile in its structure. The peptides have metal binding properties as shown by LCMS with post column addition of metal salt solutions. These results were supported by DFT calculations.

Indexed as

Cadophora malorumCyclic peptideMetal binding

Identifiers

PMID35831516
PMCPMC9279517
OpenAlexW4285388701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.