ArticleNature2022
Structure of the nutrient-sensing hub GATOR2.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
6.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 73 citations in OpenAlex.
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- WDR12 Promotes Glucose Metabolism via PFKFB4 Upregulation in Gastric Cancer.Cancer science · 2026Article
- Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion.The Journal of clinical investigation · 2026Article
- GATOR2 regulates the nutrient-dependent recruitment of GATOR1 to lysosomes.bioRxiv : the preprint server for biology · 2026Article
- Leucine-Restricted Diet Attenuates Small Intestinal Tumorigenesis in ApcFood science & nutrition · 2026Article
- Decoding the Gut-Fat-Heart Axis: From Molecular Communication Networks to Clinical Translation Strategies.International journal of molecular sciences · 2026Review
- Associations between arginine metabolism and gestational diabetes mellitus: an exploratory longitudinal study using widely targeted metabolomics.BMC pregnancy and childbirth · 2026Article
- TP53 mutations in triple-negative breast cancer cells confer sensitivity to ASCT2 inhibition via arginine uptake.Cell death & disease · 2026Article
- Integrated pan cancer analysis with breast cancer validation identifies SEC13 homolog as prognostic biomarker and immunotherapy target.Scientific reports · 2026Article
- Multi-omics dissection of heat stress reveals CIITA as a central regulator of metabolic thermotolerance in cattle (Bos taurus).Communications biology · 2026Article
- Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.Science (New York, N.Y.) · 2026Article
- Structure and function of the yeast amino acid-sensing SEAC-EGOC supercomplex.Nature structural & molecular biology · 2026Article
- Radiation-induced nuclear translocation of NPRL2 hijacks E3 ubiquitin ligases to enhance DNA repairActa pharmaceutica Sinica. B · 2026Article
- Glycolytic-Cholesterol Subtypes of Severe Asthma Reveal Distinct Immune-Inflammatory and Metabolic Phenotypes.Journal of inflammation research · 2026Article
- Metabolic alterations and redox homeostasis in ferroptosis: emerging mechanisms and therapeutic implications.Archives of medical science : AMS · 2026Article
- Putative identification of CASTOR1 as one of the targets of ganoderic acid a via thermal proteome profiling and molecular docking.Frontiers in pharmacology · 2026Article
- Article
- Architecture of the human KICSTOR and GATOR1-KICSTOR complexes.Nature structural & molecular biology · 2025Article
- Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons.Science advances · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Max L Valenstein *Whitehead Institute for Biomedical Research, Cambridge, MA, USA. mvalenst@wi.mit.edu.ORCID http://orcid.org/0000-0001-7616-0148
Kacper B Rogala *Whitehead Institute for Biomedical Research, Cambridge, MA, USA. rogala@stanford.edu.ORCID http://orcid.org/0000-0001-5997-7770
Pranav V LalgudiWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Edward J BrignoleDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4285-6128
Xin GuWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3393-6927
Robert A SaxtonWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Lynne ChantranupongWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jonas KolibiusWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Jan-Philipp QuastWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2713-778X
David M Sabatini
Whitehead Institute for Biomedical Research · USBroad Institute · USMassachusetts Institute of Technology · US
Funding
Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MMedical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MCell Growth Signaling in Cancer DevelopmentR01CA129105 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2008 to 2021
$5.9MTRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALINGR01AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2000 to 2021
$4.9MMechanistic insights into lysosomal nutrient efflux in cancerR00CA255926 · NCI · STANFORD UNIVERSITY · PI ROGALA, KACPER · 2022 to 2024
$735kMechanistic insights into lysosomal nutrient efflux in cancerK99CA255926 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI ROGALA, KACPER · 2021 to 2022
$230kElucidating the role of GATOR2 in nutrient sensing by mTORC1F30CA228229 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VALENSTEIN, MAX · 2018 to 2020
$150kCharacterization of MWS/DEN, a novel regulator of amino acid signaling to mTORC1F31CA180271 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHANTRANUPONG, LYNNE · 2013 to 2015
$128kElucidating the mechanism of leucine sensing by Sestrin2 upstream of mTORC1F31GM121093 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI SAXTON, ROBERT ANDREW · 2017 to 2017
$44kNCI NIH HHS F30 CA228229NCI NIH HHS F31 CA180271NCI NIH HHS K99 CA255926NCI NIH HHS R00 CA255926NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129105NIAID NIH HHS R01 AI047389NIGMS NIH HHS F31 GM121093NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273
Abstract
Mechanistic target of rapamycin complex 1 (mTORC1) controls growth by regulating anabolic and catabolic processes in response to environmental cues, including nutrients
Indexed as
Amino AcidsCryoelectron MicroscopyMultiprotein ComplexesNutrientsProtein SubunitsArginineCarrier ProteinsHumansIntracellular Signaling Peptides and ProteinsLeucineMechanistic Target of Rapamycin Complex 1Nuclear Pore Complex ProteinsProtein DomainsProteinsSestrinsAmino AcidsArginineCarrier ProteinsCASTOR1 protein, humanIntracellular Signaling Peptides and ProteinsLeucineMechanistic Target of Rapamycin Complex 1MIOS protein, humanMultiprotein ComplexesNuclear Pore Complex ProteinsNutrientsProteinsProtein SubunitsSEC13 protein, humanSEH1L protein, humanSESN2 protein, humanSestrinsWDR24 protein, humanWDR59 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.