Evidence map›Paper›PMID 35831502›Full record

ArticleNature2022

Within-host evolution of a gut pathobiont facilitates liver translocation.

Yi Yang, Mytien Nguyen, Varnica Khetrapal, Nicole D Sonnert, Anjelica L Martin, Haiwei Chen, Martin A Kriegel, Noah W Palm

Open access · greenAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 1 synthesis or guideline pooled it, 156 citations in OpenAlex.

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38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Yi YangDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5200-0614
Mytien NguyenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-7343-6882
Varnica KhetrapalDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Nicole D SonnertDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Anjelica L MartinDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-9669-8842
Haiwei ChenDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Martin A KriegelDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7371-0391
Noah W PalmDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. noah.palm@yale.edu.ORCID http://orcid.org/0000-0001-7262-9455
Yale University · USUniversity of Münster · DE

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
Microbial Chemical Sensing and Host ResponsesRM1GM141649 · NIGMS · YALE UNIVERSITY · PI Jason Michael Crawford, Caroline Helen Johnson · 2021 to 2026
$9.0M
A forward chemical genetic screen to illuminate the dark matter of the bioactive microbiota metabolomeDP2DK125119 · NIDDK · YALE UNIVERSITY · PI PALM, NOAH WOLCOTT · 2019 to 2019
$2.5M
Impact of dysbiosis on the development of age-related inflammationR01AG068863 · NIA · YALE UNIVERSITY · PI DIXIT, VISHWA DEEP, PALM, NOAH WOLCOTT · 2020 to 2024
$2.2M
Elucidating the pathological translocation mechanism(s) of a commensal bacterium in autoimmune liver diseaseF30AI157227 · NIAID · YALE UNIVERSITY · PI NGUYEN, MYTIEN · 2021 to 2023
$82k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS F30 AI157227NIA NIH HHS R01 AG068863NIDDK NIH HHS DP2 DK125119NIDDK NIH HHS P30 DK034989NIGMS NIH HHS RM1 GM141649
6 · The paper itself

Abstract

Gut commensal bacteria with the ability to translocate across the intestinal barrier can drive the development of diverse immune-mediated diseases

Indexed as

BacteriaBacterial TranslocationBiological EvolutionGastrointestinal MicrobiomeLiverCell WallEnterococcusGenomicsHost-Pathogen InteractionsHumansInflammationIntestinal MucosaLimosilactobacillus reuteriLymph NodesMutationStochastic Processes

Identifiers

PMID35831502
PMCPMC9308686
OpenAlexW4285083308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.