ArticleNature2022
Dopamine subsystems that track internal states.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 138 citations in OpenAlex.
- Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nature metabolism · 2023Trial
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
- Representations of the intrinsic value of information in mouse orbitofrontal cortex.Nature neuroscience · 2026Article
- Whole-brain, all-optical interrogation of neuronal dynamics underlying gut and vascular interoception in zebrafish.Nature communications · 2026Article
- Dissociable roles of prefrontal plasticity in decision-making strategy and execution of habitual behavior.Nature communications · 2026Article
- Striatal dopamine signals internal states related to behavioral performance over prolonged timescales in monkeys.bioRxiv : the preprint server for biology · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- Hypothalamic regulation of energy homeostasis: Quo vadis.Reviews in endocrine & metabolic disorders · 2026Review
- Mesolimbic dopamine signaling mediates increased hedonic feeding and food seeking in lactating mice.bioRxiv : the preprint server for biology · 2026Article
- Early ingestive experience with a high-fat diet tunes satiation and nutrient-specific appetitive behaviors.bioRxiv : the preprint server for biology · 2026Article
- Dopamine Boosts Motivation for Prosocial Effort in Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Role of the Ventral Tegmental Area in Reward and Addiction: A Comprehensive Review.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- CBMolecular psychiatry · 2026Article
- TRP Channels from Sensory Coding to Physiology.Metabolites · 2025Review
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
- Need-selective gating of dopamine neuron cue responses by real and virtual hunger.bioRxiv : the preprint server for biology · 2025Article
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis ineLife · 2025Article
- Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Elevated activity of the mesolimbic dopamine system promotes feeding during pregnancy in mice.bioRxiv : the preprint server for biology · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 3 institutions in 1 country.
James C R GroveDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Lindsay A GrayHoward Hughes Medical Institute, San Francisco, CA, USA.
Naymalis La Santa MedinaHoward Hughes Medical Institute, San Francisco, CA, USA.
Nilla SivakumarHoward Hughes Medical Institute, San Francisco, CA, USA.
Jamie S AhnHoward Hughes Medical Institute, San Francisco, CA, USA.
Timothy V CorpuzHoward Hughes Medical Institute, San Francisco, CA, USA.
Joshua D BerkeNeuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1436-6823
Anatol C KreitzerDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA.
Zachary A KnightDepartment of Physiology, University of California, San Francisco, San Francisco, CA, USA. zachary.knight@ucsf.edu.ORCID http://orcid.org/0000-0001-7621-1478
Howard Hughes Medical Institute · USUniversity of California, San Francisco · USGladstone Institutes · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MUCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6MNeural Dynamics Underlying FeedingR01DK106399 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Zachary A. Knight · 2015 to 2026
$4.8MDopaminergic mechanisms for motivation and reinforcement learningR01DA045783 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOSHUA D BERKE · 2018 to 2026
$4.1MNeural mechanisms linking need to rewardRF1NS116626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERKE, JOSHUA D, KNIGHT, ZACHARY A. · 2020 to 2020
$2.7MNeural mechanisms linking need to rewardR01NS116626 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BERKE, JOSHUA D, KNIGHT, ZACHARY A. · 2023 to 2024
$1.7MCellular-level investigation of the reward circuitry controlling drinkingF31NS120468 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GROVE, JAMES · 2020 to 2022
$125kNIDA NIH HHS R01 DA045783NIDDK NIH HHS P30 DK063720NIDDK NIH HHS P30 DK098722NIDDK NIH HHS R01 DK106399NINDS NIH HHS F31 NS120468NINDS NIH HHS R01 NS116626NINDS NIH HHS RF1 NS116626
Abstract
Food and water are rewarding in part because they satisfy our internal needs
Indexed as
DopamineDopaminergic NeuronsHypothalamusNeural PathwaysNutrientsOrganism Hydration StatusVentral Tegmental AreaAnimalsCuesDigestionEatingGastrointestinal TractMesencephalonMiceRewardTime FactorsDopamineNutrientsWater
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.