ArticleNature2022
Retrograde movements determine effective stem cell numbers in the intestine.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 64 citations in OpenAlex.
- Golgi organization regulates stem cell function in the small intestine.Nature communications · 2026Article
- Intestinal Barrier Dysfunction and Stem Cell Impairment Following Cardiac Surgery in Pigs: A Porcine Model Study.Biology · 2026Article
- Live imaging of vascular dynamics in mouse skin.The Journal of investigative dermatology · 2026Article
- Aged differentiated cells reverse into native stemness-like state by niche cytokines to sustain lifelong homeostasis and tissue repair.Nature communications · 2026Article
- Frazzled/DCC directs spatial progenitor integration ensuring steady-state intestinal turnover.Nature communications · 2026Article
- Epigenetic Gatekeeping of Intestinal Stem Cell Transformation.bioRxiv : the preprint server for biology · 2026Article
- Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety.Nature reviews. Drug discovery · 2026Review
- Unsaturated alginate oligosaccharides alleviate insulin resistance and fatty liver in non-obese NAFLD mice by regulating bile acid metabolism through gut microbiota.Metabolism open · 2025Article
- Defining the mucosal ecosystem: epithelial-mesenchymal interdependence in gastrointestinal health and disease.Nature reviews. Gastroenterology & hepatology · 2025Review
- Crosstalk between the circadian clock, intestinal stem cell niche, and epithelial cell fate decision.Genes & diseases · 2025Review
- NOX1 and NPY1R mark regional colon stem cell populations that serve as cancer origins in vivo.Nature cell biology · 2025Article
- Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositisWorld journal of stem cells · 2025Article
- Mechanical control of cell fate decisions in the skin epidermis.Nature communications · 2025Article
- Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025Review
- BMP signalling in colorectal cancer: losing the yin to WNTs yang.The Journal of pathology · 2025Review
- Epithelial genetic muscarinic receptor 3 ablation induces sex-specific modulation of colonic intestinal progenitor cells and response to intestinal injury.Journal of Crohn's & colitis · 2025Article
- Tet1 safeguards lineage allocation in intestinal stem cells.bioRxiv : the preprint server for biology · 2025Article
- Article
- Mast cells: key players in digestive system tumors and their interactions with immune cells.Cell death discovery · 2025Review
- Organoid Culture of Different Intestinal Segments from Human and Mouse.Methods in molecular biology (Clifton, N.J.) · 2025Article
Corrections and comments
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Authors and funding
23 authors at 12 institutions in 7 countries.
Maria Azkanaz *Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-5640-2154
Bernat Corominas-Murtra *Institute of Biology, University of Graz, Graz, Austria.
Saskia I J Ellenbroek *Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8007-2634
Lotte Bruens *Department of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Anna T Webb *Department of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.
Dimitrios LaskarisDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-6177-0549
Koen C OostFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.ORCID http://orcid.org/0000-0002-5162-9939
Simona J A LafirenzeDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Karl AnnusverDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.
Hendrik A MessalDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-2259-0286
Sharif IqbalInstitute of Biotechnology, HiLIFE, University of Helsinki, Helsinki, Finland.
Dustin J FlanaganCRUK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0002-3915-8281
David J HuelsOncode Institute, Utrecht, The Netherlands.
Felipe Rojas-RodríguezDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Miguel VizosoDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-9992-2851
Maria KasperDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-6117-2717
Owen J SansomCRUK Beatson Institute, Glasgow, UK.ORCID http://orcid.org/0000-0001-9540-3010
Hugo J SnippertOncode Institute, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4189-5213
Prisca LiberaliFriedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.ORCID http://orcid.org/0000-0003-0695-6081
Benjamin D SimonsWellcome Trust-Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK. bds10@cam.ac.uk.ORCID http://orcid.org/0000-0002-3875-7071
Pekka KatajistoDepartment of Cell and Molecular Biology (CMB), Karolinska Institutet, Stockholm, Sweden. pekka.katajisto@ki.se.ORCID http://orcid.org/0000-0002-3033-4189
Edouard HannezoInstitute for Science and Technology Austria, Klosterneuburg, Austria. edouard.hannezo@ist.ac.at.ORCID http://orcid.org/0000-0001-6005-1561
Jacco van RheenenDepartment of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. j.v.rheenen@nki.nl.ORCID http://orcid.org/0000-0001-8175-1647
The Netherlands Cancer Institute · NLKarolinska Institutet · SEInstitute of Science and Technology Austria · ATOncode Institute · NLUniversity of Helsinki · FIAustralian Regenerative Medicine Institute · AUCancer Research UK Scotland Institute · GBFriedrich Miescher Institute · CHRoyal Netherlands Academy of Arts and Sciences · NLUniversity Medical Center Utrecht · NLUniversity of Basel · CHWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
European Research Council 758617European Research Council 851288Medical Research Council MC_PC_17230Wellcome TrustWellcome Trust 098357/Z/12/ZWellcome Trust 219478/Z/19/Z
Abstract
The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts
Indexed as
Cell CountCell MovementIntestinesStem CellsAnimalsIntestinal MucosaIntestine, SmallMiceReceptors, G-Protein-CoupledWnt ProteinsLgr5 protein, mouseReceptors, G-Protein-CoupledWnt Proteins
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.