ArticleScientific reports2022
Mode of action of fluopyram in plant-parasitic nematodes.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- UAV-applied fluopyram enables rapid translocation and long-lasting efficacy for control of pine wilt disease.Pest management science · 2026Article
- Fluopyram analogues containing a five-membered heterocyclic ring moiety: synthesis, nematicidal activity and molecular docking study.Molecular diversity · 2026Article
- Diversity-oriented optimization of 1,2,4-oxadiazole pharmacophore for the discovery of nematicides.Molecular diversity · 2026Article
- Rhizosphere Microbial Community and Metagenomic Annotation Responses in aMicroorganisms · 2026Article
- Reviewing the thoroughness of human safety testing for succinate dehydrogenase inhibitors: fluopyram as a case study.Archives of toxicology · 2026Review
- A comprehensive review of new pesticides developed between 2015 and 2025.Journal of pesticide science · 2026Article
- Chitosan Acts as a Sustainable Strategy for Integrated Management of Root-Knot Nematodes (Plants (Basel, Switzerland) · 2026Article
- Fluopyram in agricultural ecosystems: environmental fate, microbial transformation, ecotoxicity, and resistance risks of an SDHI fungicide.Frontiers in microbiology · 2026Review
- Distinct anthelmintic classes do not affect gut bacteria, and bacteria do not alter nematocidal efficacy inmicroPublication biology · 2026Article
- Synthesis, Anthelmintic Activity, and Mechanism of Action of 5-Aryl-1Journal of agricultural and food chemistry · 2025Article
- TheInternational journal of molecular sciences · 2025Article
- A proof-of-concept experimental-theoretical model to predict pesticide resistance evolution.Heredity · 2025Article
- Design, synthesis, and nematicidal activity of novel 1,2,4-oxadiazole derivatives containing amide fragments.Molecular diversity · 2025Article
- Developing Fluopyram as a Tool to Combat Beech Leaf Disease in Managed Landscapes and Nurseries.Journal of nematology · 2025Article
- Occurrence of a population of the root-knot nematode, Meloidogyne incognita, with low sensitivity to two major nematicides, fosthiazate and fluopyram, in Japan.Pest management science · 2025Article
- Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels inAntioxidants (Basel, Switzerland) · 2025Review
- Anthelminthic Activity ofScientifica · 2025Article
- Competitive cyclization of ethyl trifluoroacetoacetate and methyl ketones with 1,3-diamino-2-propanol into hydrogenated oxazolo- and pyrimido-condensed pyridones.Beilstein journal of organic chemistry · 2025Article
- Potential of fruit seeds: Exploring bioactives and ensuring food safety for sustainable management of food waste.Food chemistry: X · 2024Article
- Residue and dissipation kinetics of novel nematicide fluopyram in rice assessed by QuEChERS-liquid chromatography-tandem mass spectrometry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-parasitic nematodes (PPN) are responsible for severe yield losses in crop production. Management is challenging as effective and safe means are rare. Recently, it has been discovered that the succinate dehydrogenase (SDH) inhibitor fluopyram is highly effective against PPN while accompanying an excellent safety profile. Here we show that fluopyram is a potent inhibitor of SDH in nematodes but not in mammals, insects and earthworm, explaining the selectivity on molecular level. As a consequence of SDH inhibition, fluopyram impairs ATP generation and causes paralysis in PPN and Caenorhabditis elegans. Interestingly, efficacy differences of fluopyram amongst PPN species can be observed. Permanent exposure to micromolar to nanomolar amounts of fluopyram prevents Meloidogyne spp. and Heterodera schachtii infection and their development at the root. Preincubation of Meloidogyne incognita J2 with fluopyram followed by a recovery period effectively reduces gall formation. However, the same procedure does not inhibit H. schachtii infection and development. Sequence comparison of sites relevant for ligand binding identified amino acid differences in SDHC which likely mediate selectivity, coincidently revealing a unique amino acid difference within SDHC conserved among Heterodera spp. Docking and C. elegans mutant studies suggest that this minute difference mediates altered sensitivity of H. schachtii towards fluopyram.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.