ArticleNature communications2022
The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses.Cell reports. Medicine · 2023Pooled it
- Research progress on the Sonic Hedgehog signaling pathway in the central nervous system: Novel insights.Neural regeneration research · 2026Article
- Noncoding RNAs in Pediatric Solid Tumors: Advances in Understanding and Critical Knowledge Gaps.Cells · 2026Review
- HHIPL2 positively governs Hedgehog signaling to accelerate non-small cell lung cancer progression via enhancing HNRNPC-mediated HNF1A mRNA stabilization.Cell death & disease · 2025Article
- Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression.Cell death and differentiation · 2025Article
- Long Non-Coding RNAs in Malignant Human Brain Tumors: Driving Forces Behind Progression and Therapy.International journal of molecular sciences · 2025Review
- Biological disturbance of MiR-425 and its application prospects in cardiovascular diseases.Frontiers in cell and developmental biology · 2025Review
- Hedgehog pathway and cancer: A new area (Review).Oncology reports · 2024Review
- CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review.Cancer cell international · 2024Article
- Comprehensive analysis indicated that NDE1 is a potential biomarker for pan-cancer and promotes bladder cancer progression.Cancer medicine · 2024Article
- Deciphering the Role of LncRNAs in Osteoarthritis: Inflammatory Pathways Unveiled.Journal of inflammation research · 2024Review
- Construction of stomach adenocarcinoma prognostic signature based on anoikis-related lncRNAs and clinical significance.The Libyan journal of medicine · 2023Article
- The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma.Journal of neuro-oncology · 2023Article
- The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review.Cancers · 2023Review
- The cancer-testis lncRNA LINC01977 promotes HCC progression by interacting with RBM39 to prevent Notch2 ubiquitination.Cell death discovery · 2023Article
- Long noncoding RNA SNHG15: A promising target in human cancers.Frontiers in oncology · 2023Review
- LncRNA ELF3-AS1 inhibits gastric cancer by forming a negative feedback loop with SNAI2 and regulates ELF3 mRNA stability via interacting with ILF2/ILF3 complex.Journal of experimental & clinical cancer research : CR · 2022Article
- Specific lncRNA signatures discriminate childhood acute leukaemias: a pilot study.Cancer cell international · 2022Article
- Global lncRNA expression profiles in medulloblastoma reveal crucial lncRNA-oncogene interactions in Sonic hedgehog and Group 4.Neuro-oncology advancesArticle
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Authors and funding
48 authors at 14 institutions in 8 countries.
Jasmin Bartl *Division of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany. jasmin.bartl@ini-research.org.ORCID 0000-0002-8737-2610
Marco Zanini *Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Flavia Bernardi *Institut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Antoine ForgetInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Lena BlümelDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Julie TalbotInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Daniel PicardDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Nan QinDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Gabriele CancilaInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Qingsong GaoSt Jude Children's Research Hospital, Memphis, TN, USA.
Soumav NathInstitut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany.
Idriss Mahoungou KoumbaDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.
Marietta WolterInstitute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.
François KuonenProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.
Maike LanginiInstitute for Molecular Medicine, Proteome Research, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.ORCID 0000-0001-8622-3261
Thomas BeezDepartment of Neurosurgery, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
Christopher MunozDepartment of Neurosurgery, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.
David PauckDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Viktoria MarquardtDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Hua YuInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Judith SouphronInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France.
Mascha KorschDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-1721-7754
Christina MöldersDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Daniel BergerDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Sarah GöbbelsDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Frauke-Dorothee MeyerDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany.
Björn SchefflerDKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ), DKTK, partner site University Hospital Essen, Düsseldorf, Germany.ORCID 0000-0001-8316-6556
Barak RotblatDepartment of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.
Sven DiederichsDivision of Cancer Research, Department of Thoracic Surgery, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, DKTK, partner site Freiburg, Freiburg i.Br, Germany.ORCID 0000-0001-7901-4752
Vijay RamaswamyDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-6557-895X
Hiromishi SuzukiDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-8858-0294
Anthony OroProgram in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6261-138X
Kai StühlerMolecular Proteomics Laboratory (MPL), BMFZ, Heinrich Heine University, Düsseldorf, Germany.
Anja StefanskiMolecular Proteomics Laboratory (MPL), BMFZ, Heinrich Heine University, Düsseldorf, Germany.
Ute FischerDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-2455-2489
Gabriel LeprivierInstitute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.
Dieter WillboldInstitut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany.
Gerhard StegerInstitut für Physikalische Biologie and Biological-Medical Research Center (BMFZ), Heinrich Heine University, Düsseldorf, Germany.
Alexander BuellDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-1161-3622
Marcel KoolHopp Children´s Cancer Center (KiTZ), Heidelberg, Germany.
Peter LichterDivision of Molecular Genetics, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Stefan M PfisterHopp Children´s Cancer Center (KiTZ), Heidelberg, Germany.ORCID 0000-0002-5447-5322
Paul A NorthcottSt Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0002-1220-5252
Michael D TaylorDevelopmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0001-7009-3466
Arndt BorkhardtDepartment of Pediatric Oncology, Hematology, and Clinical Immunology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, and DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.ORCID 0000-0002-6121-4737
Guido ReifenbergerInstitute of Neuropathology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany, DKTK, partner site Essen/Düsseldorf, Düsseldorf, Germany.
Olivier AyraultInstitut Curie, PSL Research University, CNRS UMR, INSERM, Orsay, France. olivier.ayrault@curie.fr.ORCID 0000-0002-7942-6674
Marc RemkeDivision of Pediatric Neuro-Oncogenomics, German Cancer Research Center (DKFZ), Heidelberg, Germany, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf, Düsseldorf, Germany. marc.remke@med.uni-duesseldorf.de.ORCID 0000-0002-9404-9993
German Cancer Research Center · DEHeinrich Heine University Düsseldorf · DEUniversité Paris-Sud · FRForschungszentrum Jülich · DEHospital for Sick Children · CASt. Jude Children's Research Hospital · USBen-Gurion University of the Negev · ILDüsseldorf University Hospital · DEHôpital de Beaumont · CHStanford University · USTechnical University of Denmark · DKUniversität Hamburg · DEUniversity of Freiburg · DEUniversity of Toronto · CA
Funding
REGULATING GLI FUNCTION IN HAIR FOLLICLE PROGENITORSR01AR054780 · NIAMS · STANFORD UNIVERSITY · PI ORO, ANTHONY E · 2007 to 2017
$4.3MNIAMS NIH HHS R01 AR054780
Abstract
Most lncRNAs display species-specific expression patterns suggesting that animal models of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and oncogenic pathways in humans. Among these pathways, Sonic Hedgehog (SHH) signaling is aberrantly activated in several human cancer entities. We unravel that aberrant expression of the primate-specific lncRNA HedgeHog Interacting Protein-AntiSense 1 (HHIP-AS1) is a hallmark of SHH-driven tumors including medulloblastoma and atypical teratoid/rhabdoid tumors. HHIP-AS1 is actively transcribed from a bidirectional promoter shared with SHH regulator HHIP. Knockdown of HHIP-AS1 induces mitotic spindle deregulation impairing tumorigenicity in vitro and in vivo. Mechanistically, HHIP-AS1 binds directly to the mRNA of cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) and attenuates its degradation by hsa-miR-425-5p. We uncover that neither HHIP-AS1 nor the corresponding regulatory element in DYNC1I2 are evolutionary conserved in mice. Taken together, we discover an lncRNA-mediated mechanism that enables the pro-mitotic effects of SHH pathway activation in human tumors.
Indexed as
Cerebellar NeoplasmsMedulloblastomaMicroRNAsRNA, Long NoncodingAnimalsCarrier ProteinsCell Line, TumorCell ProliferationDyneinsGene Expression Regulation, NeoplasticHedgehog ProteinsHumansMembrane GlycoproteinsMiceCarrier ProteinsDyneinsHedgehog ProteinsHHIP protein, humanHhip protein, mouseMembrane GlycoproteinsMicroRNAsRNA, Long NoncodingSHH protein, humanShh protein, mouse
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