ReviewEuropean respiratory review : an official journal of the European Respiratory Society2022
Understanding the pathogenesis of occupational coal and silica dust-associated lung disease.
Review in European respiratory review : an official journal of the European Respiratory Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Association between interleukin gene polymorphisms and the risk of pneumoconiosis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Relationship between cumulative silica exposure and silicosis: a systematic review and dose-response meta-analysis.Thorax · 2024Pooled it
- Occupational exposure to silica and risk of gastrointestinal cancers: a systematic review and meta-analysis of cohort studies.International archives of occupational and environmental health · 2024Pooled it
- The Impact of Occupational Exposures on the Risk of Idiopathic Pulmonary Fibrosis: A Systematic Review and Meta-Analysis.Annals of the American Thoracic Society · 2024Pooled it
- The hidden hazards of clay: a qualitative exploration of silica exposure and well-being in ceramic art studios.International journal of qualitative studies on health and well-being · 2026Article
- Macrophage polarization plasticity in pulmonary fibrosis: a review from pathogenesis to therapeutic targeting.Inflammopharmacology · 2026Review
- Association between polyphenols and inhalation-induced oxidative stress in chronic lung diseases: A systematic review.Biomedical reports · 2026Article
- Silicosis from dry-cutting engineered stone in the fabrication of countertops.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners.iScience · 2026Article
- Deciphering Pathogenesis of Silica Nanoparticle-Induced Airway Remodeling and Fibrosis: Insights from a Human Patient Cohort and a Murine Model.Nanomaterials (Basel, Switzerland) · 2026Article
- Health inequities in the comorbid association between pneumoconiosis and chronic obstructive pulmonary disease: a nationwide study of age-related heterogeneity.Respiratory research · 2026Article
- Noninvasive early detection and grading of pneumoconiosis via plasma proteomics and machine learning: PRSS3 as a potential biomarker.Clinical proteomics · 2026Article
- Research on the Prediction of Coal Workers' Pneumoconiosis Based on Easily Detectable Clinical Data: Machine Learning Model Development and Validation Study.JMIR medical informatics · 2026Article
- NLRP3 Inflammasome Inhibition by Xuanfei Baidu Decoction Attenuates Pulmonary Inflammation and Collagen Deposition in Silicosis.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers.Toxics · 2026Article
- Long-term survival and the critical role of competing risks in pneumoconiosis: a large-scale retrospective cohort study.Frontiers in public health · 2026Article
- Tools of the trade: leveraging 3DFrontiers in pharmacology · 2026Review
- Post-COVID spirometric abnormalities in workers with intermittent high-altitude exposure: A cross-sectional study in Peru.PloS one · 2026Article
- Environmental exposure to rare earth elements and respiratory health: an emerging public health concern.Frontiers in public health · 2026Review
- The role of whole lung lavage in pneumoconiosis patients with pulmonary diffusion limitation.Frontiers in medicine · 2026Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Workers in the mining and construction industries are at increased risk of respiratory and other diseases as a result of being exposed to harmful levels of airborne particulate matter (PM) for extended periods of time. While clear links have been established between PM exposure and the development of occupational lung disease, the mechanisms are still poorly understood. A greater understanding of how exposures to different levels and types of PM encountered in mining and construction workplaces affect pathophysiological processes in the airways and lungs and result in different forms of occupational lung disease is urgently required. Such information is needed to inform safe exposure limits and monitoring guidelines for different types of PM and development of biomarkers for earlier disease diagnosis. Suspended particles with a 50% cut-off aerodynamic diameter of 10 µm and 2.5 µm are considered biologically active owing to their ability to bypass the upper respiratory tract's defences and penetrate deep into the lung parenchyma, where they induce potentially irreversible damage, impair lung function and reduce the quality of life. Here we review the current understanding of occupational respiratory diseases, including coal worker pneumoconiosis and silicosis, and how PM exposure may affect pathophysiological responses in the airways and lungs. We also highlight the use of experimental models for better understanding these mechanisms of pathogenesis. We outline the urgency for revised dust control strategies, and the need for evidence-based identification of safe level exposures using clinical and experimental studies to better protect workers' health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.