Evidence map›Paper›PMID 35830999›Full record

ReviewSaudi medical journal2022

Cyclooxygenase-2 immunohistochemical expression is associated with worse prognosis in breast cancer: Retrospective study and literature review.

Jaudah Al-Maghrabi, Mohamad N Khabaz

Open access · diamondAbstract readReview
In one paragraph

Review in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jaudah Al-MaghrabiFrom the Department of Pathology (Al-Maghrabi), Faculty of Medicine; from the Department of Pathology (Khabaz), Rabigh Faculty of Medicine, King Abdulaziz University, and from the Department of Pathology (Al-Maghrabi), King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi Arabia.
Mohamad N KhabazFrom the Department of Pathology (Al-Maghrabi), Faculty of Medicine; from the Department of Pathology (Khabaz), Rabigh Faculty of Medicine, King Abdulaziz University, and from the Department of Pathology (Al-Maghrabi), King Faisal Specialist Hospital and Research Centre, Jeddah, Kingdom of Saudi Arabia.
King Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the immunohistochemistry phenotype of cyclooxygenase-2 (COX-2) in breast cancer (BC) and to correlate it with histological and clinical prognostic factors.

methodsThis retrospective study utilized COX-2 monoclonal antibody in an immunohistochemistry staining of tissue microarrays slides of 570 cases of previously diagnosed BC and with 52 of normal breast tissues from breast specimens resected for benign lesions or reconstruction (fibroadenoma and normal breast epithelium). This project was carried out in the Laboratory of pathology, King Abdulaziz University, Jeddah, Saudi Arabia, between September 2019 and September 2021.

resultsThe present data showed an important connection between the COX-2 expression phenotype and BC compared to benign breast tissues (

conclusionCyclooxygenase-2 is a valuable marker that could facilitate BC diagnosis and prognosis.

Indexed as

Breast NeoplasmsCyclooxygenase 2FemaleHumansImmunohistochemistryPrognosisRetrospective StudiesCyclooxygenase 2breast cancerCOX-2cyclooxygenase-2immunohistochemistry

Identifiers

PMID35830999
PMCPMC9749694
OpenAlexW4285404249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.