ArticleJournal of sleep research2022
Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort.
Article in Journal of sleep research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Insomnia Symptoms in a Swiss Population-Based Cohort: Prevalence, Clinical Correlates and Polysomnographic Alterations.Journal of sleep research · 2026Article
- Association Between Serum Trace Elements and Obstructive Sleep Apnea in Iranian Adults: Multiple-exposure Models.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2026Article
- Hydrogen as a Potential Modulator: Implications for Mast Cell-Sleep-Wake Rhythm-Melatonin Interactions in Sleep Disorders.Molecular neurobiology · 2026Review
- Sleep Abnormalities and Risk of Alzheimer's Disease.Current neurology and neuroscience reports · 2025Review
- Programmed cell death in the cognitive impairment of obstructive sleep apnea.Cell & bioscience · 2025Review
- The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats.Biology of sex differences · 2025Article
- The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats.Research square · 2024Article
- Associations between the multitrajectory neuroplasticity of neuronavigated rTMS-mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Causal Relationship Between Micronutrient and Sleep Disorder: A Mendelian Randomization Study.Nature and science of sleep · 2024Article
- Corrigendum.Journal of sleep research · 2023Article
- Ferroptosis-related genes are considered as potential targets for CPAP treatment of obstructive sleep apnea.Frontiers in neurology · 2023Article
- Abnormal brain iron accumulation in obstructive sleep apnea: A quantitative MRI study in the HypnoLaus cohort.Journal of sleep research · 2022Article
Corrections and comments
- Erratum issuedCorrigendum.2023
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Obstructive sleep apnea syndrome (OSA) may be a risk factor for Alzheimer's disease. One of the hallmarks of Alzheimer's disease is disturbed iron homeostasis leading to abnormal iron deposition in brain tissue. To date, there is no empirical evidence to support the hypothesis of altered brain iron homeostasis in patients with obstructive sleep apnea as well. Data were analysed from 773 participants in the HypnoLaus study (mean age 55.9 ± 10.3 years) who underwent polysomnography and brain MRI. Cross-sectional associations were tested between OSA parameters and the MRI effective transverse relaxation rate (R2*) - indicative of iron content - in 68 grey matter regions, after adjustment for confounders. The group with severe OSA (apnea-hypopnea index ≥30/h) had higher iron levels in the left superior frontal gyrus (F
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