Evidence map›Paper›PMID 35830911›Full record

ArticleEnvironmental research2022

A prospective study of arsenic and manganese exposures and maternal blood pressure during gestation.

Faye V Andrews, Adam Branscum, Perry Hystad, Ellen Smit, Sakila Afroz, Mostofa Golam, Omar Sharif, Mohammad Rahman, Quazi Quamruzzaman, David C Christiani and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Manganese exposure is a risk for brain atrophy.Hypertension research : official journal of the Japanese Society of Hypertension · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Faye V AndrewsSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA; Oregon Clinical and Translational Research Institute, Oregon Health and Sciences University, Portland, OR, USA. Electronic address: andrewsf@oregonstate.edu.
Adam BranscumSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Perry HystadSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Ellen SmitSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Sakila AfrozDhaka Community Hospital Trust, Dhaka, Bangladesh.
Mostofa GolamDhaka Community Hospital Trust, Dhaka, Bangladesh.
Omar SharifDhaka Community Hospital Trust, Dhaka, Bangladesh.
Mohammad RahmanDhaka Community Hospital Trust, Dhaka, Bangladesh.
Quazi QuamruzzamanDhaka Community Hospital Trust, Dhaka, Bangladesh.
David C ChristianiHarvard T.H. Chan School of Public Health, Department of Environmental Health, Harvard University, Boston, MA, USA.
Molly L KileSchool of Biological and Population Health Sciences, College of Public Health and Human Sciences, Oregon State University, Corvallis, OR, USA.
Dhaka Community Hospital Trust · BDOregon State University · USHarvard University · US

Funding

Superfund Metal Mixtures, Biomarkers and NeurodevelopmentP42ES016454 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI BELLINGER, DAVID C · 2010 to 2015
$10.1M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Arsenic Exposure and Birth Outcomes in BangladeshR01ES015533 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHRISTIANI, DAVID C · 2007 to 2011
$2.1M
Developmental Exposure to Arsenic and Immune Function in ChildrenR01ES023441 · NIEHS · OREGON STATE UNIVERSITY · PI KILE, MOLLY L · 2014 to 2018
$1.5M
NCATS NIH HHS TL1 TR002371NIEHS NIH HHS P42 ES016454NIEHS NIH HHS R01 ES015533NIEHS NIH HHS R01 ES023441
6 · The paper itself

Abstract

backgroundPregnancy is a sensitive time for maternal cardiovascular functioning and exposures to arsenic or manganese may adversely affect blood pressure (BP).

objectivesThis study examined the associations between arsenic and manganese exposures and maternal BP measured during pregnancy. Effect modification by pre-pregnancy body mass index (BMI) was evaluated.

methodsPregnant women (N = 1522) were recruited for a prospective cohort study in Bangladesh (2008-2011). Exposure to arsenic and manganese was measured in drinking water at <16 weeks gestation and toenails at one-month postpartum. Systolic and diastolic BP were measured monthly. Linear mixed models estimated mean BP and differences in mean BP over gestation for arsenic or manganese exposures and adjusted for covariates.

resultsArsenic levels had an increasing dose-response association with maternal BP after 25 weeks gestation. Effect modification was observed for BMI. Participants with lower BMI (<23 kg/m

conclusionArsenic exposures during pregnancy were consistently associated with increased average maternal systolic and diastolic BP. The effect of manganese on BP was less consistent.

Indexed as

ArsenicDrinking WaterBlood PressureFemaleHumansIonsManganesePregnancyProspective StudiesArsenicDrinking WaterIonsManganeseCardiovascular diseaseCVDDiastolicEnvironmental contaminantsMetal exposuresPregnancySystolicTrimester

Identifiers

PMID35830911
PMCPMC9629670
OpenAlexW4284990166

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.