Evidence map›Paper›PMID 35830886›Full record

GuidelineJournal of the National Comprehensive Cancer Network : JNCCN2022

Soft Tissue Sarcoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.

Margaret von Mehren, John M Kane, Mark Agulnik, Marilyn M Bui, Janai Carr-Ascher, Edwin Choy, Mary Connelly, Sarah Dry, Kristen N Ganjoo, Ricardo J Gonzalez and 24 more

Registry-linked trialOpen access · bronzeAbstract readPractice Guideline
In one paragraph

Guideline in Journal of the National Comprehensive Cancer Network : JNCCN, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06263231 (A Multicenter, Randomized, Phase 3 Study to Assess the Efficacy and Safety of INtratumorally Administered INT230-6), which is not on this map. Cited by 239 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
239citing papers in PubMed, 2 pooled it
50.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06263231 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

A Multicenter, Randomized, Phase 3 Study to Assess the Efficacy and Safety of INtratumorally Administered INT230-6 (SHAO, VINblastine, CIsplatin) Compared With US Standard of Care in Adults With Locally Recurrent, InoperaBLE, or Metastatic Soft Tissue Sarcomas (INVINCIBLE-3)

TypeinterventionalSponsorIntensity Therapeutics, Inc.Ran2024 to 2028Enrolled333ConditionsSarcoma,Soft TissueArmsINT230-6, Eribulin, Trabectedin, Pazopanib
3 · Its place in the literature

Who cites it

239 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,120 citations in OpenAlex.

  1. Pooled it
  2. Systematic review of 99 extremity bone malignancy survival prediction models.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
    Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Gene Expression Profiling ofJournal of clinical practice and research · 2026
    Article
  15. Article
  16. Article
  17. Review
  18. Diagnosis and Management of Soft-Tissue Sarcomas: Current Insights.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026
    Review
  19. Review
  20. Article

179 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 3 countries.

Margaret von Mehren1Fox Chase Cancer Center.
John M Kane2Roswell Park Comprehensive Cancer Center.
Mark Agulnik3City of Hope National Medical Center.
Marilyn M Bui4Moffitt Cancer Center.
Janai Carr-Ascher5UC Davis Comprehensive Cancer Center.
Edwin Choy6Massachusetts General Hospital Cancer Center.
Mary Connelly7The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Sarah Dry8UCLA Jonsson Comprehensive Cancer Center.
Kristen N Ganjoo9Stanford Cancer Institute.
Ricardo J Gonzalez4Moffitt Cancer Center.
Ashley Holder10O'Neal Comprehensive Cancer Center at UAB.
Jade Homsi11UT Southwestern Simmons Comprehensive Cancer Center.
Vicki Keedy12Vanderbilt-Ingram Cancer Center.
Ciara M Kelly13Memorial Sloan Kettering Cancer Center.
Edward Kim14Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance.
David Liebner7The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Martin McCarter15University of Colorado Cancer Center.
Sean V McGarry16Fred & Pamela Buffett Cancer Center.
Nathan W Mesko17Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute.
Christian Meyer18The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins.
Alberto S Pappo19St. Jude Children's Research Hospital/The University of Tennessee Health Science Center.
Amanda M Parkes20University of Wisconsin Carbone Cancer Center.
Ivy A Petersen21Mayo Clinic Cancer Center.
Seth M Pollack22Robert H. Lurie Comprehensive Cancer Center of Northwestern University.
Matthew Poppe23Huntsman Cancer Institute at the University of Utah.
Richard F Riedel24Duke Cancer Institute.
Scott Schuetze25University of Michigan Rogel Cancer Center.
Jacob Shabason26Abramson Cancer Center at the University of Pennsylvania.
Jason K Sicklick27UC San Diego Moores Cancer Center.
Matthew B Spraker28Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine.
Melissa Zimel29UCSF Helen Diller Family Comprehensive Cancer Center; and.
Lisa E Hang30National Comprehensive Cancer Network.
Hema Sundar30National Comprehensive Cancer Network.
Mary Anne Bergman30National Comprehensive Cancer Network.
National Comprehensive Cancer NetworkCancer Institute (WIA) · INMoffitt Cancer Center · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · USBarnes-Jewish Hospital · USBreast Cancer Research Foundation · USCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZACity Of Hope National Medical Center · USFox Chase Cancer Center · USKettering University · USMassachusetts General Hospital · USRobert Morris University Illinois · USSidney Kimmel Comprehensive Cancer Center · USSusan Thompson Buffett Foundation · USThe University of Texas Southwestern Medical Center · USUC Davis Comprehensive Cancer CenterUCLA Jonsson Comprehensive Cancer CenterUCSF Helen Diller Family Comprehensive Cancer Center · USUniversity Hospitals Seidman Cancer Center · USUniversity of California, San Diego · US

Funding

UC Davis Paul Calabresi K12 Clinical Oncology Research Career Development ProgramK12CA138464 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BIRKELAND, ANDREW CHARLES, LARA, PRIMO N. · 2011 to 2025
$11.4M
Targeting Drug-Resistant Cancer Stem Cell Niches of Gastrointestinal Stromal TumorR01CA226803 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2019 to 2023
$2.1M
FDA HHS R01 FD006334NCI NIH HHS K12 CA138464NCI NIH HHS R01 CA226803
6 · The paper itself

Abstract

Soft tissue sarcomas (STS) are rare malignancies of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Soft Tissue Sarcoma provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as retroperitoneal/intra-abdominal STS, desmoid tumors, and rhabdomyosarcoma. This portion of the NCCN Guidelines discusses general principles for the diagnosis and treatment of retroperitoneal/intra-abdominal STS, outlines treatment recommendations, and reviews the evidence to support the guidelines recommendations.

Indexed as

SarcomaSoft Tissue NeoplasmsExtremitiesHumansMedical Oncology

Identifiers

PMID35830886
PMCPMC10186762
OpenAlexW4285097283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.