ArticleCell reports2022
CaMKII binds both substrates and activators at the active site.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37citing papers in PubMed
–field-weighted citation impact
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Who cites it
37 citing papers in PubMed.
- CaMKIIα holoenzymes self-organize into chain-like mesoscale clusters.Science advances · 2026Article
- Discovery of a novel CaMKⅡα inhibitor by machine learning, molecular docking and molecular dynamics simulation.Journal of computer-aided molecular design · 2026Article
- A tandem recruitment site in the pseudokinase scaffold PEAK3 is subject to phosphorylation-dependent regulation and cancer-associated mutations.The Journal of biological chemistry · 2026Article
- CaMKII nucleates an osmotic protein supercomplex to induce cellular bleb expansion.The EMBO journal · 2026Article
- CaMKII as a Multimodal Signalling Hub in Neural Connectivity and Vulnerability.Molecular neurobiology · 2026Review
- Rab14 restricts pathogens by promoting V-ATPase lysosomal delivery to drive lysosomal acidification.Nature communications · 2026Article
- Structural dynamics of mixed-subunit CaMKIIα/β heterododecamers filmed by high-speed AFM.Nature communications · 2025Article
- Widely Used CaMKII Regulatory Segment Mutations Cause Tight Actinin Binding and Dendritic Spine Enlargement in Unstimulated Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The Janus face of CaMKII: from memory consolidation to neurotoxic switch in Alzheimer's disease.Archives of toxicology · 2025Review
- CaMKII Drives Synaptic Maturation by Coordinating Spine Remodeling and Receptor Segregation via Liquid-Liquid Phase Separation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Uncovering the molecular basis of kinase activity and substrate recognition with phospho-PCA.bioRxiv : the preprint server for biology · 2025Article
- Degradation of CaMKII is stimulated by its active conformation.The Journal of biological chemistry · 2025Article
- Article
- The CaMKII D135N mutation blocks kinase activity and reduces GluN2B binding.bioRxiv : the preprint server for biology · 2025Article
- An AlphaFold guided model for the evolution of the CaMKII interactome.bioRxiv : the preprint server for biology · 2025Article
- MuSK is a substrate for CaMK2β but this interaction is dispensable for MuSK activation in vivo.Scientific reports · 2025Article
- Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.Nature communications · 2025Article
- Article
- Identification of Critical Phosphorylation Sites Enhancing Kinase Activity With a Bimodal Fusion Framework.Molecular & cellular proteomics : MCP · 2025Article
- A revised view of the role of CaMKII in learning and memory.Nature neuroscience · 2025Review
Corrections and comments
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Authors and funding
14 authors.
Can ÖzdenDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.
Roman SloutskyDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Tomohiro MitsugiDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Nicholas SantosDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Emily AgnelloDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Christl GaubitzDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Joshua FosterMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.
Emily LapinskasDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Edward A EspositoMalvern Panalytical, Northampton, MA 01060, USA.
Takeo SaneyoshiDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Brian A KelchDepartment of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Scott C GarmanDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Yasunori HayashiDepartment of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Margaret M StrattonDepartment of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: mstratton@umass.edu.
Funding
Structural Studies of Lysosomal Storage DiseasesR01DK076877 · NIDDK · UNIVERSITY OF MASSACHUSETTS AMHERST · PI GARMAN, SCOTT C. · 2007 to 2021
$4.3MUnraveling the molecular events driven by CaMKII in Ca2+-coupled cellsR35GM145376 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Margaret M Stratton · 2022 to 2026
$2.1MCaMKII biophysics and its role in LTP: Undergraduate SupplementR01GM123157 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI STRATTON, MARGARET M · 2018 to 2022
$1.7MNIDDK NIH HHS R01 DK076877NIGMS NIH HHS R01 GM123157NIGMS NIH HHS R35 GM145376
Abstract
Ca
Indexed as
Calcium-Calmodulin-Dependent Protein Kinase Type 2Protein Processing, Post-TranslationalCalciumCatalytic DomainPhosphorylationCalciumCalcium-Calmodulin-Dependent Protein Kinase Type 2AMPA-type glutamate receptorCa(2+)/calmodulin dependent protein kinase IICP: Molecular biologyLTPNMDA-type glutamate receptorTiam1X-ray crystallography
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.