Evidence map›Paper›PMID 35830746›Full record

ArticleWater research2022

Identification and quantification of bioactive compounds suppressing SARS-CoV-2 signals in wastewater-based epidemiology surveillance.

Mohamed Bayati, Hsin-Yeh Hsieh, Shu-Yu Hsu, Chenhui Li, Elizabeth Rogers, Anthony Belenchia, Sally A Zemmer, Todd Blanc, Cindy LePage, Jessica Klutts and 21 more

Open access · hybridAbstract read
In one paragraph

Article in Water research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors at 3 institutions in 1 country.

Mohamed BayatiSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA.
Hsin-Yeh HsiehSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA.
Shu-Yu HsuSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA; Center for Agroforestry, University of Missouri, Columbia, MO 65211, USA.
Chenhui LiSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA.
Elizabeth RogersSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA; Center for Agroforestry, University of Missouri, Columbia, MO 65211, USA.
Anthony BelenchiaBureau of Environmental Epidemiology, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, MO 65109, USA.
Sally A ZemmerWater Protection Program, Missouri Department of Natural Resources, Jefferson City, MO 65101, USA.
Todd BlancWater Protection Program, Missouri Department of Natural Resources, Jefferson City, MO 65101, USA.
Cindy LePageWater Protection Program, Missouri Department of Natural Resources, Jefferson City, MO 65101, USA.
Jessica KluttsWater Protection Program, Missouri Department of Natural Resources, Jefferson City, MO 65101, USA.
Melissa ReynoldsBureau of Environmental Epidemiology, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, MO 65109, USA.
Elizabeth SemkiwBureau of Environmental Epidemiology, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, MO 65109, USA.
Hwei-Yiing JohnsonBureau of Environmental Epidemiology, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, MO 65109, USA.
Trevor FoleyMissouri Department of Corrections, Jefferson City, MO 65109, USA.
Chris G WiebergWater Protection Program, Missouri Department of Natural Resources, Jefferson City, MO 65101, USA.
Jeff WenzelBureau of Environmental Epidemiology, Division of Community and Public Health, Missouri Department of Health and Senior Services, Jefferson City, MO 65109, USA.
Terri LyddonDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Mary LePiqueDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Clayton RushfordDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Braxton SalcedoDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Kara YoungDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Madalyn GrahamDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Reinier SuarezDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Anarose FordDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Zhentian LeiMetabolomics Center, Department of Biochemistry, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Lloyd SumnerMetabolomics Center, Department of Biochemistry, Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Brian P MooneyCharles W. Gehrke Proteomics Center, Bond Life Sciences Center, University of Missouri-Columbia, Columbia, MO 65211, USA.
Xing WeiCharles W. Gehrke Proteomics Center, Bond Life Sciences Center, University of Missouri-Columbia, Columbia, MO 65211, USA.
C Michael GreenliefCharles W. Gehrke Proteomics Center, Bond Life Sciences Center, University of Missouri-Columbia, Columbia, MO 65211, USA.
Marc C JohnsonDepartment of Molecular Microbiology and Immunology, University of Missouri, School of Medicine and the Christopher S. Bond Life Sciences Center, Columbia, MO 65211, USA.
Chung-Ho LinSchool of Natural Resources, University of Missouri, Columbia, MO 65211, USA; Center for Agroforestry, University of Missouri, Columbia, MO 65211, USA. Electronic address: linchu@missouri.edu.
University of Missouri · USMissouri Department of Health and Senior Services · USMissouri Department of Natural Resources · US

Funding

Wastewater Detection of COVID-19U01DA053893 · NIDA · MISSOURI STATE DEPT/ HEALTH & SENIOR SRV · PI WENZEL, JEFF · 2021 to 2022
$4.0M
NIDA NIH HHS U01 DA053893
6 · The paper itself

Abstract

Recent SARS-CoV-2 wastewater-based epidemiology (WBE) surveillance have documented a positive correlation between the number of COVID-19 patients in a sewershed and the level of viral genetic material in the wastewater. Efforts have been made to use the wastewater SARS-CoV-2 viral load to predict the infected population within each sewershed using a multivariable regression approach. However, reported clear and sustained variability in SARS-CoV-2 viral load among treatment facilities receiving industrial wastewater have made clinical prediction challenging. Several classes of molecules released by regional industries and manufacturing facilities, particularly the food processing industry, can significantly suppress the SARS-CoV-2 signals in wastewater by breaking down the lipid-bilayer of the membranes. Therefore, a systematic ranking process in conjugation with metabolomic analysis was developed to identify the wastewater treatment facilities exhibiting SARS-CoV-2 suppression and identify and quantify the chemicals suppressing the SARS-COV-2 signals. By ranking the viral load per diagnosed case among the sewersheds, we successfully identified the wastewater treatment facilities in Missouri, USA that exhibit SARS-CoV-2 suppression (significantly lower than 5 × 10

Indexed as

COVID-19SARS-CoV-2HumansRNA, ViralWastewaterWastewater-Based Epidemiological MonitoringRNA, ViralWastewaterDetergentsMetabolomicsSARS-COV-2 suppressionSurfactantsWastewater surveillance

Identifiers

PMID35830746
PMCPMC9253601
OpenAlexW4283816749

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.