Evidence map›Paper›PMID 35830708›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2022

The impact of frailty on adverse outcomes after transcatheter aortic valve replacement in older adults: A retrospective cohort study.

Lauren Dautzenberg, Tessa T M van Aarle, Pieter R Stella, Marielle Emmelot-Vonk, Marcel A Weterman, Huiberdina L Koek

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In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. The impact of frailty on adverse outcomes after transcatheter aortic valve replacement in older adults: A retrospective cohort study.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2022
    Article
  9. Doing procedures for patients rather than to patients.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lauren DautzenbergDepartment of Geriatric Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0003-2502-9988
Tessa T M van AarleDepartment of Geriatric Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Pieter R StellaDepartment of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Marielle Emmelot-VonkDepartment of Geriatric Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Marcel A WetermanDepartment of Geriatric Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Huiberdina L KoekDepartment of Geriatric Medicine, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.
Utrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTranscatheter aortic valve replacement (TAVR) is an effective alternative to surgical aortic valve replacement for patients who are at increased surgical risk. Consequently, frailty is common in patients undergoing TAVR.

objectivesThis study aims to investigate the impact of frailty on outcomes following TAVR.

methodsA retrospective cohort study was conducted, including all TAVR candidates who visited the geriatric outpatient clinic for preoperative screening. Frailty status was assessed according to the Groningen Frailty Indicator. The primary outcome of the study was defined as the occurrence of postoperative complications, and this was evaluated according to the Clavien-Dindo classification. An additional analysis was performed to assess the impact of frailty on 1-year all-cause mortality and complications within 30 days of TAVR according to the Valve Academic Research Consortium (VARC-2) criteria. The VARC-2 criteria provide harmonized endpoint definitions for TAVR studies.

resultsIn total, 431 patients with a mean age of 80.8 ± 6.2 years were included, of whom 56% were female. Frailty was present in 36% of the participants. Frailty was associated with a higher risk of the composite outcome of complications [adjusted odds ratio (OR): 1.55 (95% confidence interval, CI: 1.03-2.34)], 30-day mortality [adjusted OR: 4.84 (95% CI: 1.62-14.49)], 3-month mortality [adjusted OR: 2.52 (95% CI: 1.00-6.28)] and 1-year mortality [adjusted OR: 2.96 (95% CI: 1.46-6.00)].

conclusionsFrailty is common in TAVR patients and is associated with an increased overall risk of postoperative complications, particularly mortality. Increased optimization of screening and treatment of frailty in the guidelines for valvular heart diseases is recommended.

Indexed as

Aortic Valve StenosisFrailtyTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic ValveFemaleHumansMalePostoperative ComplicationsProspective StudiesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcomecomplicationsfrailtymortalityolder adulttranscatheter aortic valve replacementvulnerable

Identifiers

PMID35830708
PMCPMC9545405
OpenAlexW4285394945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.