Evidence map›Paper›PMID 35830603›Full record

ArticleMicrobial biotechnology2023

Fundamental insights in early-stage inclusion body formation.

Julian Kopp, Benjamin Bayer, Christoph Slouka, Gerald Striedner, Mark Dürkop, Oliver Spadiut

Abstract read
In one paragraph

Article in Microbial biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julian KoppResearch Division Integrated Bioprocess Development, Institute of Chemical, Environmental and Bioscience, Vienna, Austria.ORCID 0000-0003-4975-7103
Benjamin BayerDepartment of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Christoph SloukaResearch Division Integrated Bioprocess Development, Institute of Chemical, Environmental and Bioscience, Vienna, Austria.
Gerald StriednerDepartment of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Mark DürkopDepartment of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Oliver SpadiutResearch Division Integrated Bioprocess Development, Institute of Chemical, Environmental and Bioscience, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-stage inclusion body formation is still mysterious. Literature is ambiguous about the existence of rod-shaped protein aggregates, a potential sponge-like inclusion body scaffold as well as the number of inclusion bodies per Escherichia coli cell. In this study, we verified the existence of rod-shaped inclusion bodies, confirmed their porous morphology, the presence of multiple protein aggregates per cell and modelled inclusion body formation as function of the number of generations.

Indexed as

Escherichia coliProtein AggregatesInclusion BodiesRecombinant ProteinsProtein AggregatesRecombinant Proteins

Identifiers

PMID35830603
PMCPMC10128139

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.