Evidence map›Paper›PMID 35829999›Full record

ArticleNeurotoxicity research2022

Epigallocatechin-3-Gallate Pretreatment Improves Autologous Adipose-derived Stem Cells Against Rheumatoid Arthritis-induced Neuroinflammation in the Brain of Collagen-induced Rats.

Ming-Shan Chen, Bruce Chi-Kang Tsai, Maria Angelina Sitorus, Chia-Hua Kuo, Wei-Wen Kuo, Tung-Sheng Chen, Chien-Yao Fu, Tsung-Jung Ho, Chih-Yang Huang, Da-Tong Ju

Abstract read
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Article in Neurotoxicity research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
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  3. Heliyon · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 1 country.

Ming-Shan ChenDepartment of Anesthesiology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi, Taiwan.
Bruce Chi-Kang TsaiCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Maria Angelina SitorusCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Tung-Sheng ChenSchool of Life Science, National Taiwan Normal University, 88 Ting-Chow Rd, Sec 4, Taipei, Taiwan.
Chien-Yao FuOrthopaedic Department, Armed Forces General Hospital, Taichung, Taiwan.
Tsung-Jung HoIntegration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chih-Yang Huang *Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung, Taiwan. cyhuang@mail.cmu.edu.tw.
Da-Tong Ju *Department of Neurological Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. wxyz670628@yahoo.com.tw.
Tzu Chi Foundation · TWAsia University · TWChina Medical University · TWNational Defense Medical Center · TWNational Taiwan Normal University · TWTri-Service General Hospital · TWTzu Chi University · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue-derived mesenchymal stem cells (ADSC) exert neuroprotective and anti-inflammatory effects. ADSCs are considered potential therapeutics for rheumatoid arthritis (RA), an inflammatory, multisystemic autoimmune disease. Epigallocatechin-3-gallate (EGCG), the major polyphenolic compound in green tea, has strong anti-inflammatory and antioxidant properties. This study aimed to investigate whether EGCG has a synergistic effect on the neuroprotective effects of ADSCs to protect the RA-damaged brain. Wistar rats were classified into four groups: sham, RA, RA + ADSCs (1 × 10

Indexed as

Arthritis, RheumatoidCatechinNeuroprotective AgentsAnimalsAntioxidantsBrainCollagenNeuroinflammatory DiseasesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, WistarStem CellsTeaAntioxidantsCatechinCollagenepigallocatechin gallateNeuroprotective AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTeaBrainEpigallocatechin-3-gallateNeuroprotectionRheumatoid arthritisStem cell

Identifiers

PMID35829999
OpenAlexW4285088106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.