Evidence map›Paper›PMID 35829947›Full record

Trial reportSleep & breathing = Schlaf & Atmung2023

Adherence and efficacy of mandibular advancement splint treatment of sleep-disordered breathing during pregnancy: a pilot study.

Nelly Huynh, Léa Drouin-Gagné, Camille Gilbert, Jean-Patrick Arcache, Pierre Rompré, Anne-Maude Morency, Robert Gagnon, John Kimoff, Sushmita Pamidi

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03138291 (Efficacy of Oral Appliances on Obstructive Sleep Apnea During Pregnancy), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03138291 nacompletednot on this map

Efficacy of Oral Appliances on Obstructive Sleep Apnea During Pregnancy

TypeinterventionalSponsorUniversité de MontréalRan2016 to 2023Enrolled17ConditionsSleep Apnea, Obstructive, Pregnancy RelatedArmsSomnodent
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nelly HuynhFaculty of Dental Medicine, Orthodontic Clinic, Université de Montréal, 3525 chemin Queen Mary, Montreal, QC, H3C1H9, Canada. nelly.huynh@umontreal.ca.ORCID 0000-0003-4836-2476
Léa Drouin-GagnéFaculty of Dental Medicine, Orthodontic Clinic, Université de Montréal, 3525 chemin Queen Mary, Montreal, QC, H3C1H9, Canada.
Camille GilbertFaculty of Dental Medicine, Orthodontic Clinic, Université de Montréal, 3525 chemin Queen Mary, Montreal, QC, H3C1H9, Canada.
Jean-Patrick ArcacheFaculty of Dental Medicine, Orthodontic Clinic, Université de Montréal, 3525 chemin Queen Mary, Montreal, QC, H3C1H9, Canada.
Pierre RompréFaculty of Dental Medicine, Orthodontic Clinic, Université de Montréal, 3525 chemin Queen Mary, Montreal, QC, H3C1H9, Canada.
Anne-Maude MorencyMcGill University Health Centre, Montreal, QC, Canada.
Robert GagnonMcGill University Health Centre, Montreal, QC, Canada.
John KimoffMcGill University Health Centre, Montreal, QC, Canada.
Sushmita PamidiMcGill University Health Centre, Montreal, QC, Canada.
McGill University Health Centre · CAUniversité de Montréal · CAMcGill University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSleep-disordered breathing (SDB) is common in pregnancy and is associated with adverse health consequences for both mother and child. Mandibular advancement splints (MAS) have been shown to improve sleep quality, daytime sleepiness and snoring in non-pregnant women. The effectiveness of MAS for treating SDB in pregnancy is unknown. This pilot study aimed to evaluate the efficacy and adherence to MAS in pregnant women with SDB.

methodsWomen with mild-moderate SDB (apnea-hypopnea index (AHI) 10-29/h) on level 2 polysomnography (PSG) performed at 22.0 ± 5.5 weeks' gestation were treated with a MAS during pregnancy to 6 months postpartum. An embedded micro-recorder measured adherence. PSG was repeated while on titrated treatment, and off treatment in the postpartum period.

resultsAmong 17 women completing the study, MAS was worn ≥ 4 h/night for 57.5 ± 36.7% of nights during the antepartum period. While using MAS, nightly snoring time decreased from 25.9 ± 24.5% at baseline to 6.4 ± 7.8% when treated during pregnancy (p = .003). AHI decreased from 17.6 ± 5.1 to 12.9 ± 6.3 (p = .02) and fell by ≥ 30% and below 15/h in 60% of participants. During the postpartum period, MAS was used for ≥ 4 h/night on 24.8 ± 27.9% of nights. Moreover, the mean AHI off MAS was 17.9 ± 13.1; 88% of women had persistent SDB (AHI ≥ 10).

conclusionsIn this cohort, treatment efficacy and objective adherence were variable. Device use was less frequent in the postpartum period even though a substantial number of women had persistent SDB after delivery. Clinical trial registered with  www. CLINICALTRIALS: gov number: NCT03138291.

Indexed as

Sleep Apnea, ObstructiveSleep Apnea SyndromesFemaleHumansOcclusal SplintsPilot ProjectsPregnancySnoringMandibular advancementObstructive sleep apnoeaOral appliancePolysomnographyPregnancy

Identifiers

PMID35829947
OpenAlexW4285392775

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.