Evidence map›Paper›PMID 35829945›Full record

ArticleJournal of autism and developmental disorders2023

Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study.

Rachael A Muscatello, Aaron Pachol, Alexandra Romines, Ian Smith, Blythe A Corbett

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rachael A MuscatelloDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Village at Vanderbilt, 1500 21st Avenue South, Nashville, TN, 37212, USA. Rachael.a.muscatello.1@vumc.org.ORCID http://orcid.org/0000-0002-9862-1686
Aaron PacholDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Village at Vanderbilt, 1500 21st Avenue South, Nashville, TN, 37212, USA.
Alexandra RominesCollege of Arts and Sciences, Vanderbilt University, Nashville, TN, USA.
Ian SmithCollege of Arts and Sciences, Vanderbilt University, Nashville, TN, USA.
Blythe A CorbettDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Village at Vanderbilt, 1500 21st Avenue South, Nashville, TN, 37212, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Examining Stress and Arousal Across Pubertal Development in ASDR01MH111599 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CORBETT, BLYTHE ANNE · 2017 to 2025
$3.9M
NCATS NIH HHS UL1 TR000445NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD083211NIMH NIH HHS R01 MH111599
6 · The paper itself

Abstract

Prolonged dysregulation of the autonomic nervous system (ANS) may increase propensity for physical or psychiatric illness. The current study examined differences in respiratory sinus arrhythmia (RSA) regulation in 215 adolescents with or without autism spectrum disorder (ASD) at Time 1 (T1; 10-13 years old) and 1 year later (Time 2; T2). Linear mixed effects models demonstrated lower RSA regulation in ASD, and a small interaction effect, showing blunted change in RSA from T1 to T2. Developmental differences in RSA regulation were particularly notable in females with ASD and those taking psychotropic medications. Results expand previous findings of reduced parasympathetic regulation in ASD by revealing a blunted developmental slope, indicating diagnostic differences may persist or worsen over time, particularly in females.

Indexed as

Autism Spectrum DisorderRespiratory Sinus ArrhythmiaAdolescentAutonomic Nervous SystemChildFemaleHumansLinear ModelsLongitudinal StudiesMaleAutismDevelopmentParasympatheticRespiratory sinus arrhythmiaSex

Identifiers

PMID35829945
PMCPMC9949914
OpenAlexW4285089395

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.