Evidence map›Paper›PMID 35829862›Full record

ArticleHead and neck pathology2022

Inter- and Intrarater Reliability and Agreement Among Danish Head and Neck Pathologists Assessing Extranodal Extension in Lymph Node Metastases from Oropharyngeal Squamous Cell Carcinomas.

Chadi Nimeh Abdel-Halim, Max Rohde, Stine Rosenkilde Larsen, Tina Marie Green, Benedicte Parm Ulhøi, Nina Claire Woller, Oke Gerke, Poul Flemming Høilund-Carlsen, Jens Ahm Sørensen, Christian Godballe

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Chadi Nimeh Abdel-HalimDepartment of ORL - Head & Neck Surgery and Audiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense, Denmark. chadi.abdelhalim@rsyd.dk.ORCID http://orcid.org/0000-0003-3029-6204
Max RohdeDepartment of ORL - Head & Neck Surgery and Audiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense, Denmark.
Stine Rosenkilde LarsenDepartment of Pathology, Odense University Hospital, J. B. Winsløws Vej 15, 5000, Odense, Denmark.
Tina Marie GreenDepartment of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, 5000, Odense, Denmark.
Benedicte Parm UlhøiDepartment of Pathology, Aarhus University Hospital, Palle Juul Jensens Boulevard 99, 8200, Aarhus N, Denmark.
Nina Claire WollerDepartment of Pathology, Copenhagen University Hospital, Inge Lehmanns Vej 14, Copenhagen, Denmark.
Oke GerkeDepartment of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, 5000, Odense, Denmark.
Poul Flemming Høilund-CarlsenDepartment of Nuclear Medicine, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense, Denmark.
Jens Ahm SørensenDepartment of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19.3, 5000, Odense, Denmark.
Christian GodballeDepartment of ORL - Head & Neck Surgery and Audiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000, Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DKAarhus University Hospital · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExtranodal extension (ENE) in lymph node metastases is one of the most important prognostic factors in head and neck squamous cell carcinomas. Studies have shown inconsistency among pathologists in the assessment of ENE. The aims of this study were: (1) to determine the interrater and intrarater reliability and agreement in the assessment of ENE among Danish pathologists and (2) to test if a standardized assessment method may increase interrater agreement.

methodsFour Danish head and neck pathologists assessed ENE presence or absence in 120 histological slides from lymph nodes with oropharyngeal squamous cell carcinoma metastases (first round). Subsequently, guidelines were introduced to the pathologists and a new assessment was performed (second round). Finally, two of the pathologists assessed the slides to determine intrarater reliability and agreement (third round).

resultsInterrater kappa coefficients varied between 0.57 and 0.67 in the first round and between 0.59 and 0.72 in the second round. The intrarater agreement between round 2 and 3 was 0.88 for pathologist 1 and 0.92 for pathologist 2 with resulting kappa coefficients of 0.76 (95% CI 0.64-0.88) and 0.84 (95% CI 0.74-0.94), respectively.

conclusionWe found a moderate level of reliability and agreement among pathologists for ENE in lymph node metastases from oropharyngeal squamous cell carcinomas. The intrarater reliability and agreement was generally higher than interrater measures. Interrater agreement was slightly improved by standardized assessment.

Indexed as

Head and Neck NeoplasmsHumansLymphatic MetastasisReproducibility of ResultsSquamous Cell Carcinoma of Head and NeckExtranodal extensionHead and neck cancerHistopathologyInterobserverLymph node metastasesOropharynxReliabilitySquamous cell carcinoma

Identifiers

PMID35829862
PMCPMC9729471
OpenAlexW4285083722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.