ArticleScience China. Life sciences2023
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.
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Article in Science China. Life sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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23 citing papers in PubMed, 32 citations in OpenAlex.
- Decoding Primary Open-Angle Glaucoma: A Multi-Omics Approach to Identify Druggable Effector Genes.Investigative ophthalmology & visual science · 2026Article
- Reduction of Lipid Droplets Modulates the Injury Response and Enhances CNTF-Induced Axon Regeneration Following Optic Nerve Crush.Molecular neurobiology · 2026Article
- Lipid homeostasis plays a critical role in inherited and acquired retinal diseases.Communications biology · 2026Review
- Tubulin hyperglutamylation induces retinal degeneration by disrupting ciliary architecture and protein trafficking.Zoological research · 2026Article
- Association of High-Density Lipoprotein Cholesterol with Macular Structure in Nonglaucomatous Individuals.Ophthalmology science · 2026Article
- Exploring the role of VAV2 rare variants in primary open-angle glaucoma: genetic insights and pathophysiological mechanisms.Science China. Life sciences · 2026Article
- Applications of single-cell transcriptomics in glaucoma research: from the aqueous humor outflow pathway to retinal ganglion cell neurodegeneration.Frontiers in physiology · 2026Review
- Genetic Association of Primary Angle-Closure Glaucoma and Disease Progression.Clinical & experimental ophthalmology · 2025Article
- Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration.Neural regeneration research · 2025Article
- High-fat diet alters retinal lipid composition and gene expression networks in mice.BMC biology · 2025Article
- Retinoid X receptor agonist 9CDHRA mitigates retinal ganglion cell apoptosis and neuroinflammation in a mouse model of glaucoma.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Effects of Different Components of Buyang Huanwu Tang on the PPARInternational journal of genomics · 2025Article
- Associations between serum lipid levels and the macular retinal volumes in patients with diabetes.PloS one · 2025Article
- Serum lipid and lipoprotein profiles and their association with intraocular pressure in primary open-angle glaucoma: an observational cross-sectional study in the Chinese population.Lipids in health and disease · 2024Observational
- Profile of Lipoprotein Subclasses in Chinese Primary Open-Angle Glaucoma Patients.International journal of molecular sciences · 2024Article
- Leukemia Inhibitory Factor Protects against Degeneration of Cone Photoreceptors Caused by RPE65 Deficiency.Current medicinal chemistry · 2024Article
- ABCA1 Deletion Does Not Affect Aqueous Humor Outflow Function in Mice.Journal of ophthalmology · 2024Article
- Quantifying ABCA1/apoA-1 Signaling Pathways with AFM Imaging and Lipidomic Analysis.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma.Science China. Life sciences · 2023Article
- Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1H NMR Spectroscopy Results From the UK Biobank.Investigative ophthalmology & visual science · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 5 institutions in 1 country.
Jialiang YangKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yuhong ChenDepartment of Ophthalmology and Visual Science, Eye and Ear Nose Throat (ENT) Hospital, Fudan University, Shanghai, 200032, China.
Tongdan ZouKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Bai XueKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Fang YangKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Xiangzhou WangSchool of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yibo HuoSchool of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Boyun YanSchool of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Yuxia XuKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Shiyu HeKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yi YinInstitute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, 610093, China.
Jing WangInstitute of Chengdu Biology, Sichuan Translational Medicine Hospital, Chinese Academy of Sciences, Chengdu, 610093, China.
Xiong ZhuKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Lin ZhangKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yu ZhouKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Zhengfu TaiKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Ping ShuaiKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Man YuDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Qian LuoDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Yilian ChengDepartment of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Bo GongKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Xianjun ZhuKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Jing ZhangSchool of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, China.
Xinghuai SunDepartment of Ophthalmology and Visual Science, Eye and Ear Nose Throat (ENT) Hospital, Fudan University, Shanghai, 200032, China.
Ying LinKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Houbin ZhangKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. houbin_zhang@yahoo.com.
Zhenglin YangKey Laboratory for Human Disease Gene Study of Sichuan Province and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. yangzhenglin@cashq.ac.cn.
University of Electronic Science and Technology of China · CNChengdu Institute of Biology · CNEye & ENT Hospital of Fudan University · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies have suggested a link between primary open-angle glaucoma and the function of ABCA1. ABCA1 is a key regulator of cholesterol efflux and the biogenesis of high-density lipoprotein (HDL) particles. Here, we showed that the POAG risk allele near ABCA1 attenuated ABCA1 expression in cultured cells. Consistently, POAG patients exhibited lower ABCA1 expression, reduced HDL, and higher cholesterol in white blood cells. Ablation of Abca1 in mice failed to form HDL, leading to elevated cholesterol levels in the retina. Counting retinal ganglion cells (RGCs) by using an artificial intelligence (AI) program revealed that Abca1-deficient mice progressively lost RGCs with age. Single-cell RNA sequencing (scRNA-seq) revealed aberrant oxidative phosphorylation in the Abca1
Indexed as
ATP Binding Cassette Transporter 1CholesterolRetinal Ganglion CellsAnimalsArtificial IntelligenceAtorvastatinCell LineGenome-Wide Association StudyGlaucoma, Open-AngleHomeostasisMiceAbca1 protein, mouseAtorvastatinATP Binding Cassette Transporter 1CholesterolABCA1atorvastatincholesterolglaucomaHDLretinal ganglion cell
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