Evidence map›Paper›PMID 35829783›Full record

Trial reportEuropean journal of nutrition2022

Small-quantity lipid-based nutrient supplements, with or without added zinc, do not cause excessive fat deposition in Burkinabe children: results from a cluster-randomized community trial.

Souheila Abbeddou, Elizabeth Yakes Jimenez, Sonja Y Hess, Jérome W Somé, Jean Bosco Ouédraogo, Kenneth H Brown

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00944281 (A Randomized, Double-blind, Controlled Trial in Rural Burkina Faso to Determine the Optimal Amount of Zinc to Include in a Lipid-based Nutrient Supplement), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00944281 nacompletednot on this map

A Randomized, Double-blind, Controlled Trial in Rural Burkina Faso to Determine the Optimal Amount of Zinc to Include in a Lipid-based Nutrient Supplement (LNS). Part of the iLiNS Study

TypeinterventionalSponsorUniversity of California, DavisRan2010 to 2014Enrolled3,220ConditionsMalnutritionArmsLNS-Zn5, LNS-Zn10, LNS-Zn0, Suppl-Zn5
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Souheila AbbeddouPublic Health Nutrition Unit, Department of Public Health and Primary Care, Ghent University, Campus UZ Gent, Corneel Heymanslaan 10, 9000, Ghent, Belgium. Souheila.Abbeddou@UGent.be.ORCID http://orcid.org/0000-0002-1363-0170
Elizabeth Yakes JimenezDepartments of Pediatrics and Internal Medicine and College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Sonja Y HessDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA.
Jérome W SoméInstitut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso.
Jean Bosco OuédraogoInstitut de Recherche en Sciences de la Santé, Bobo-Dioulasso, Burkina Faso.
Kenneth H BrownDepartment of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA.
Institut de Recherche en Sciences de la Santé · BFUniversity of California, Davis · USGhent University Hospital · BEUniversity of New Mexico · US

Funding

bill and melinda gates foundation OPP49817
6 · The paper itself

Abstract

purposePublic health interventions to address stunting and wasting should be evaluated for possibly contributing to obesity risk. The present study tested the hypothesis that small-quantity lipid-based nutrient supplements (SQ-LNS) might increase fat deposition, and that additional zinc provided via SQ-LNS or in the form of dispersible tablets would increase fat-free mass (FFM) accretion.

methodsUsing a two-stage, cluster-randomized trial design, 34 communities were randomly assigned to the intervention cohort (IC) or non-intervention cohort (NIC), and family compounds within the IC were randomly assigned to receive different amounts of zinc (0, 5 or 10 mg zinc) incorporated in SQ-LNS or 5 mg zinc in the form of dispersible tablets along with treatment for diarrhea, malaria and fever. Body composition was assessed in a subset of IC (n = 201) and NIC (n = 74) children at 9 and 18 months using the deuterium dilution method. A mixed linear model was used to examine average change in FFM and % fat mass (%FM) among intervention groups and by cohort.

resultsChildren in the IC had significantly greater change in FFM (Mean (95% Confidence Interval)) (1.57 (1.49, 1.64) kg) compared to the NIC (1.35 (1.23, 1.46) kg; p = 0.005). There were no significant differences in the change in %FM between the NIC and IC or among the intervention groups.

conclusionSQ-LNS, along with morbidity treatment increased weight gain and FFM in young children from 9 to 18 months of age without increasing FM deposition. Additional zinc supplementation did not affect changes in FFM or %FM.

trial registrationThe study was registered as a clinical trial with the US National Institute of Health ( www. CLINICALTRIALS: gov ; NCT00944281).

Indexed as

Dietary SupplementsZincChildChild, PreschoolDeuteriumHumansInfantLipidsNutrientsDeuteriumLipidsNutrientsZincBody compositionChildDeuterium dilution techniqueFat-free massFat massSmall-quantity lipid-based nutrient supplementsZinc

Identifiers

PMID35829783
PMCPMC9596589
OpenAlexW4285393915

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.